WEKO3
インデックスリンク
アイテム
{"_buckets": {"deposit": "768f39db-e060-4416-b354-3faba5d6eb45"}, "_deposit": {"created_by": 18, "id": "47424", "owners": [18], "pid": {"revision_id": 0, "type": "depid", "value": "47424"}, "status": "published"}, "_oai": {"id": "oai:kanazawa-u.repo.nii.ac.jp:00047424", "sets": ["2816"]}, "author_link": ["287", "77302"], "item_9_biblio_info_8": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2018-05-23", "bibliographicIssueDateType": "Issued"}, "bibliographicPageStart": "6p.", "bibliographicVolumeNumber": "2015-04-01 - 2018-03-31", "bibliographic_titles": [{"bibliographic_title": "平成29(2017)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"}, {"bibliographic_title": "2017 Fiscal Year Final Research Report", "bibliographic_titleLang": "en"}]}]}, "item_9_creator_33": {"attribute_name": "著者別表示", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Morishita, Eriko"}], "nameIdentifiers": [{"nameIdentifier": "77302", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "50251921", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=50251921"}]}]}, "item_9_description_21": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "骨髄バンクからの非血縁者間同種骨髄移植患者・ドナーのDNAと臨床データを用いて、Fc receptor-like 3遺伝子の一塩基置換(s3761959)が生存率(全生存)と治療関連死亡と関連があることを明らかにした。\nまた、移植後急性移植片対宿主病(GVHD)予防などに用いられる免疫抑制剤タクロリムス(FK506)は血管内皮細胞を傷害し、血管透過性亢進を惹起すること、遺伝子組換えトロンボモジュリン前投与が内皮機能障害を改善する可能性を示唆した。", "subitem_description_type": "Abstract"}, {"subitem_description": "We investigated the impact of the Fc receptor-like 3 variant(s3761959) on transplantation outcomes in a cohort of 1029 patients who underwent unrelated HLA-matched bone marrow transplantation (BMT) for hematologic malignancies through the Japan Marrow Donor Program. We revealed that the recipient T/T genotype was associated with significantly better overall survival rates and a lower incidence of treatment-related death than the recipient C/C or C/T genotype.\nTacrolimus (FK506) calcineurin inhibitor is an effective immunosuppressant which is essential to prevent allograft rejection. We showed that FK506 impaired the function of coagulation and fibrinolytic systems and permeability in the human umbilical endothelial cells in vitro. Moreover, pre-treatment of recombinant thrombomodulin prevented these endothelial dysfunction.", "subitem_description_type": "Abstract"}]}, "item_9_description_22": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "研究課題/領域番号:13555218, 研究期間(年度):2015-04-01 - 2018-03-31", "subitem_description_type": "Other"}, {"subitem_description": "出典:研究課題「ヘムオキシゲナーゼ-1が造血幹細胞移植後治療成績におよぼす効果と新規治療戦略」課題番号13555218\n(KAKEN:科学研究費助成事業データベース(国立情報学研究所)) \n(https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K08643/15K08643seika/)を加工して作成", "subitem_description_type": "Other"}]}, "item_9_description_5": {"attribute_name": "提供者所属", "attribute_value_mlt": [{"subitem_description": "金沢大学医薬保健研究域保健学系", "subitem_description_type": "Other"}]}, "item_9_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.24517/00053751", "subitem_identifier_reg_type": "JaLC"}]}, "item_9_relation_28": {"attribute_name": "関連URI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "https://kaken.nii.ac.jp/search/?qm=50251921"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://kaken.nii.ac.jp/search/?qm=50251921", "subitem_relation_type_select": "URI"}}, {"subitem_relation_name": [{"subitem_relation_name_text": "https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K08643/"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K08643/", "subitem_relation_type_select": "URI"}}, {"subitem_relation_name": [{"subitem_relation_name_text": "https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K08643/15K08643seika/"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K08643/15K08643seika/", "subitem_relation_type_select": "URI"}}]}, "item_9_version_type_25": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "森下, 英里子"}], "nameIdentifiers": [{"nameIdentifier": "287", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "50251921", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=50251921"}, {"nameIdentifier": "50251921", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=50251921"}, {"nameIdentifier": "50251921", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000050251921"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-04-22"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "ME-PR-MORISHITA-E-kaken 2018-6p.pdf", "filesize": [{"value": "113.4 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 113400.0, "url": {"label": "ME-PR-MORISHITA-E-kaken 2018-6p.pdf", "url": "https://kanazawa-u.repo.nii.ac.jp/record/47424/files/ME-PR-MORISHITA-E-kaken 2018-6p.pdf"}, "version_id": "75cadb2e-b6c5-4067-8f5a-6010d0e48a13"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "造血幹細胞移植", "subitem_subject_scheme": "Other"}, {"subitem_subject": "移植後合併症", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ヘムオキシゲナーゼ-1(HO-1)", "subitem_subject_scheme": "Other"}, {"subitem_subject": "一塩基置換", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Fc receptor-like 3遺伝子", "subitem_subject_scheme": "Other"}, {"subitem_subject": "タクロリムス(FK506)", "subitem_subject_scheme": "Other"}, {"subitem_subject": "遺伝子組換えトロンボモジュリン", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "research report", "resourceuri": "http://purl.org/coar/resource_type/c_18ws"}]}, "item_title": "ヘムオキシゲナーゼ-1が造血幹細胞移植後治療成績におよぼす効果と新規治療戦略", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "ヘムオキシゲナーゼ-1が造血幹細胞移植後治療成績におよぼす効果と新規治療戦略"}, {"subitem_title": "The impact of hemoxygenase-1(HO-1) on the treatment outcome after bone marrow transplantation and the possibility of HO-1 as a new therapeutic target", "subitem_title_language": "en"}]}, "item_type_id": "9", "owner": "18", "path": ["2816"], "permalink_uri": "https://doi.org/10.24517/00053751", "pubdate": {"attribute_name": "公開日", "attribute_value": "2019-04-22"}, "publish_date": "2019-04-22", "publish_status": "0", "recid": "47424", "relation": {}, "relation_version_is_last": true, "title": ["ヘムオキシゲナーゼ-1が造血幹細胞移植後治療成績におよぼす効果と新規治療戦略"], "weko_shared_id": -1}
ヘムオキシゲナーゼ-1が造血幹細胞移植後治療成績におよぼす効果と新規治療戦略
https://doi.org/10.24517/00053751
https://doi.org/10.24517/0005375168f3121b-8568-4b50-8610-87406e8da454
名前 / ファイル | ライセンス | アクション |
---|---|---|
ME-PR-MORISHITA-E-kaken 2018-6p.pdf (113.4 kB)
|
Item type | 報告書 / Research Paper(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2019-04-22 | |||||
タイトル | ||||||
タイトル | ヘムオキシゲナーゼ-1が造血幹細胞移植後治療成績におよぼす効果と新規治療戦略 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | The impact of hemoxygenase-1(HO-1) on the treatment outcome after bone marrow transplantation and the possibility of HO-1 as a new therapeutic target | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00053751 | |||||
ID登録タイプ | JaLC | |||||
著者別表示 |
Morishita, Eriko
× Morishita, Eriko |
|||||
提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域保健学系 | |||||
書誌情報 |
平成29(2017)年度 科学研究費補助金 基盤研究(C) 研究成果報告書 en : 2017 Fiscal Year Final Research Report 巻 2015-04-01 - 2018-03-31, p. 6p., 発行日 2018-05-23 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 骨髄バンクからの非血縁者間同種骨髄移植患者・ドナーのDNAと臨床データを用いて、Fc receptor-like 3遺伝子の一塩基置換(s3761959)が生存率(全生存)と治療関連死亡と関連があることを明らかにした。 また、移植後急性移植片対宿主病(GVHD)予防などに用いられる免疫抑制剤タクロリムス(FK506)は血管内皮細胞を傷害し、血管透過性亢進を惹起すること、遺伝子組換えトロンボモジュリン前投与が内皮機能障害を改善する可能性を示唆した。 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We investigated the impact of the Fc receptor-like 3 variant(s3761959) on transplantation outcomes in a cohort of 1029 patients who underwent unrelated HLA-matched bone marrow transplantation (BMT) for hematologic malignancies through the Japan Marrow Donor Program. We revealed that the recipient T/T genotype was associated with significantly better overall survival rates and a lower incidence of treatment-related death than the recipient C/C or C/T genotype. Tacrolimus (FK506) calcineurin inhibitor is an effective immunosuppressant which is essential to prevent allograft rejection. We showed that FK506 impaired the function of coagulation and fibrinolytic systems and permeability in the human umbilical endothelial cells in vitro. Moreover, pre-treatment of recombinant thrombomodulin prevented these endothelial dysfunction. |
|||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:13555218, 研究期間(年度):2015-04-01 - 2018-03-31 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:研究課題「ヘムオキシゲナーゼ-1が造血幹細胞移植後治療成績におよぼす効果と新規治療戦略」課題番号13555218 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K08643/15K08643seika/)を加工して作成 |
|||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=50251921 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=50251921 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K08643/ | |||||
関連名称 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K08643/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K08643/15K08643seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K08643/15K08643seika/ |