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Keratinocyte differentiation induces APOBEC3A, 3B, and mitochondrial DNA hypermutation
https://doi.org/10.24517/00053820
https://doi.org/10.24517/0005382055319b7e-7ce0-457b-a581-7b48d00ac11c
名前 / ファイル | ライセンス | アクション |
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ME-PR-KITAMURA-K-27930-z.pdf (2.5 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-04-05 | |||||
タイトル | ||||||
タイトル | Keratinocyte differentiation induces APOBEC3A, 3B, and mitochondrial DNA hypermutation | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00053820 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Wakaea, Kousho
× Wakaea, Kousho× Nishiyama, Tomoaki× Kondo, Satoru× Izuka, Takashi× Que, Lusheng× Chen, Cong× Kase, Kina× Kitamura, Kouichi× Md , Monjurul× Wang, Zhe× Ahasan, Md Monjurul× Nakamura, Mitsuhiro× Fujiwara, Hiroshi× Yoshizaki, Tomokazu× Hosomochi, Kazuyoshi× Tajima, Atsushi× Nakahara, Tomomi× Kiyono, Tohru× Muramatsu, Masamichi |
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著者別表示 |
西山, 智明
× 西山, 智明× 近藤, 悟× 加瀬, 希奈× 喜多村, 晃一× 中村, 充宏× 藤原, 浩× 吉崎, 智一× 田嶋, 敦× 村松, 正道 |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域医学系 | |||||
書誌情報 |
Scientific Reports en : 8 巻 1, p. 9745, 発行日 2018-12-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2045-2322 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1038/s41598-018-27930-z | |||||
出版者 | ||||||
出版者 | Springer Nature | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Mitochondrial DNA (mtDNA) mutations are found in many types of cancers and suspected to be involved in carcinogenesis, although the mechanism has not been elucidated. In this study, we report that consecutive C-to-T mutations (hypermutations), a unique feature of mutations induced by APOBECs, are found in mtDNA from cervical dysplasia and oropharyngeal cancers. In vitro, we found that APOBEC3A (A3A) and 3B (A3B) expression, as well as mtDNA hypermutation, were induced in a cervical dysplastic cell line W12 when cultured in a differentiating condition. The ectopic expression of A3A or A3B was sufficient to hypermutate mtDNA. Fractionation of W12 cell lysates and immunocytochemical analysis revealed that A3A and A3B could be contained in mitochondrion. These results suggest that mtDNA hypermutation is induced upon keratinocyte differentiation, and shed light on its molecular mechanism, which involves A3s. The possible involvement of mtDNA hypermutations in carcinogenesis is also discussed. © 2018 The Author(s). | |||||
権利 | ||||||
権利情報 | Copyright © 2018 The Author(s). | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.nature.com/articles/s41598-018-27930-z | |||||
関連名称 | https://www.nature.com/articles/s41598-018-27930-z |