WEKO3
インデックスリンク
アイテム
{"_buckets": {"deposit": "9c924ab5-e70d-47a9-9184-c2b57c48067e"}, "_deposit": {"created_by": 18, "id": "47523", "owners": [18], "pid": {"revision_id": 0, "type": "depid", "value": "47523"}, "status": "published"}, "_oai": {"id": "oai:kanazawa-u.repo.nii.ac.jp:00047523", "sets": ["1134"]}, "author_link": ["100", "84605", "78961", "24841", "2474", "84617", "78959", "78962", "11754", "84611", "2735", "84619", "84609", "84616", "24836", "77011", "22247", "84618", "151", "84612", "84610"], "item_4_biblio_info_8": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2018-04", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "4634", "bibliographicPageStart": "4627", "bibliographicVolumeNumber": "15", "bibliographic_titles": [{"bibliographic_title": "Oncology Letters"}]}]}, "item_4_creator_33": {"attribute_name": "著者別表示", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "棟居, 聖一"}], "nameIdentifiers": [{"nameIdentifier": "2474", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "10399040", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=10399040"}]}, {"creatorNames": [{"creatorName": "原島, 愛"}], "nameIdentifiers": [{"nameIdentifier": "78959", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "50705522", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=50705522"}]}, {"creatorNames": [{"creatorName": "武内 , 章彦"}], "nameIdentifiers": [{"nameIdentifier": "2735", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "70512218", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=70512218"}]}, {"creatorNames": [{"creatorName": "土屋, 弘行"}], "nameIdentifiers": [{"nameIdentifier": "151", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "40227434", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=40227434"}, {"nameIdentifier": "40227434", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=40227434"}, {"nameIdentifier": "40227434", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000040227434"}]}, {"creatorNames": [{"creatorName": "山本, 靖彦"}], "nameIdentifiers": [{"nameIdentifier": "100", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "20313637", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=20313637"}, {"nameIdentifier": "20313637", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=20313637"}, {"nameIdentifier": "20313637", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000020313637"}]}]}, "item_4_description_21": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Receptor for advanced glycation end-products (RAGE) is a pattern recognition receptor implicated in the pathogenesis of certain types of cancer. In the present study, papaverine was identified as a RAGE inhibitor using the conversion to small molecules through optimized‑peptide strategy drug design system. Papaverine significantly inhibited RAGE‑dependent nuclear factor κ‑B activation driven by high mobility group box‑1, a RAGE ligand. Using RAGE‑ or dominant‑negative RAGE‑expressing HT1080 human fibrosarcoma cells, the present study revealed that papaverine suppressed RAGE‑dependent cell proliferation and migration dose‑dependently. Furthermore, papaverine significantly inhibited cell invasion. The results of the present study suggested that papaverine could inhibit RAGE, and provided novel insights into the field of RAGE biology, particularly anticancer therapies.", "subitem_description_type": "Abstract"}]}, "item_4_description_22": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "Embargo Period 6 months", "subitem_description_type": "Other"}]}, "item_4_description_5": {"attribute_name": "提供者所属", "attribute_value_mlt": [{"subitem_description": "金沢大学医薬保健研究域医学系", "subitem_description_type": "Other"}]}, "item_4_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.24517/00053847", "subitem_identifier_reg_type": "JaLC"}]}, "item_4_publisher_17": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Spandidos Publications"}]}, "item_4_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.3892/ol.2018.7902", "subitem_relation_type_select": "DOI"}}]}, "item_4_relation_28": {"attribute_name": "関連URI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "https://www.spandidos-publications.com/10.3892/ol.2018.7902"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.spandidos-publications.com/10.3892/ol.2018.7902", "subitem_relation_type_select": "URI"}}]}, "item_4_rights_23": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Copyright © 2018, Spandidos Publications. All rights reserved."}]}, "item_4_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1792-1074", "subitem_source_identifier_type": "ISSN"}]}, "item_4_version_type_25": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "El‑Far, Ali Hafez Ali MohammedTsuchiya Hiroshi Yamamoto Hazem M.E. Shaheen Yasser S. El‑Sayed Shuhei Kawano Sei‑Ichi Tanuma Yasuhiko Yamamoto"}], "nameIdentifiers": [{"nameIdentifier": "84605", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Munesue, Seiichi"}], "nameIdentifiers": [{"nameIdentifier": "78962", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "10399040", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=10399040"}]}, {"creatorNames": [{"creatorName": "Harashima, Ai"}], "nameIdentifiers": [{"nameIdentifier": "78961", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "50705522", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=50705522"}]}, {"creatorNames": [{"creatorName": "Satoh, Akira"}], "nameIdentifiers": [{"nameIdentifier": "11754", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shindo, Mika"}], "nameIdentifiers": [{"nameIdentifier": "84609", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakajima, Shingo"}], "nameIdentifiers": [{"nameIdentifier": "84610", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Inada, Mana"}], "nameIdentifiers": [{"nameIdentifier": "84611", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tanaka, Mariko"}], "nameIdentifiers": [{"nameIdentifier": "84612", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takeuchi, Akihiko"}], "nameIdentifiers": [{"nameIdentifier": "22247", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "70512218", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=70512218"}, {"nameIdentifier": "70512218", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=70512218"}, {"nameIdentifier": "70512218", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000070512218"}]}, {"creatorNames": [{"creatorName": "Tsuchiya, Hiroyuki"}], "nameIdentifiers": [{"nameIdentifier": "77011", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "40227434", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=40227434"}]}, {"creatorNames": [{"creatorName": "Yamamoto, Hiroshi"}], "nameIdentifiers": [{"nameIdentifier": "24841", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "00115198", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=00115198"}]}, {"creatorNames": [{"creatorName": "Shaheen, Hazem M.E."}], "nameIdentifiers": [{"nameIdentifier": "84616", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "El‑Sayed, Yasser S."}], "nameIdentifiers": [{"nameIdentifier": "84617", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kawano, Shuhei"}], "nameIdentifiers": [{"nameIdentifier": "84618", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tanuma, Sei‑Ichi"}], "nameIdentifiers": [{"nameIdentifier": "84619", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamamoto, Yasuhiko"}], "nameIdentifiers": [{"nameIdentifier": "24836", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "20313637", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=20313637"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-04-12"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "ME-PR-MUNESUE-S-4627.pdf", "filesize": [{"value": "1.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 1200000.0, "url": {"label": "ME-PR-MUNESUE-S-4627.pdf", "url": "https://kanazawa-u.repo.nii.ac.jp/record/47523/files/ME-PR-MUNESUE-S-4627.pdf"}, "version_id": "6f14c1f9-a837-49ad-87d3-10d9b9ff0933"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Cancer malignancy", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Fibrosarcoma cells", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Papaverine", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Receptor for advanced glycation end-products", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "In vitro anticancer effects of a RAGE inhibitor discovered using a structure-based drug design system.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "In vitro anticancer effects of a RAGE inhibitor discovered using a structure-based drug design system."}]}, "item_type_id": "4", "owner": "18", "path": ["1134"], "permalink_uri": "https://doi.org/10.24517/00053847", "pubdate": {"attribute_name": "公開日", "attribute_value": "2019-04-12"}, "publish_date": "2019-04-12", "publish_status": "0", "recid": "47523", "relation": {}, "relation_version_is_last": true, "title": ["In vitro anticancer effects of a RAGE inhibitor discovered using a structure-based drug design system."], "weko_shared_id": -1}
In vitro anticancer effects of a RAGE inhibitor discovered using a structure-based drug design system.
https://doi.org/10.24517/00053847
https://doi.org/10.24517/00053847253c8300-f58b-4982-81b2-09588258db25
名前 / ファイル | ライセンス | アクション |
---|---|---|
ME-PR-MUNESUE-S-4627.pdf (1.2 MB)
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||||
---|---|---|---|---|---|---|---|---|
公開日 | 2019-04-12 | |||||||
タイトル | ||||||||
タイトル | In vitro anticancer effects of a RAGE inhibitor discovered using a structure-based drug design system. | |||||||
言語 | ||||||||
言語 | eng | |||||||
資源タイプ | ||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
資源タイプ | journal article | |||||||
ID登録 | ||||||||
ID登録 | 10.24517/00053847 | |||||||
ID登録タイプ | JaLC | |||||||
著者 |
El‑Far, Ali Hafez Ali MohammedTsuchiya Hiroshi Yamamoto Hazem M.E. Shaheen Yasser S. El‑Sayed Shuhei Kawano Sei‑Ichi Tanuma Yasuhiko Yamamoto
× El‑Far, Ali Hafez Ali MohammedTsuchiya Hiroshi Yamamoto Hazem M.E. Shaheen Yasser S. El‑Sayed Shuhei Kawano Sei‑Ichi Tanuma Yasuhiko Yamamoto
WEKO
84605
× Munesue, Seiichi× Harashima, Ai× Satoh, Akira× Shindo, Mika× Nakajima, Shingo× Inada, Mana× Tanaka, Mariko× Takeuchi, Akihiko× Tsuchiya, Hiroyuki× Yamamoto, Hiroshi× Shaheen, Hazem M.E.× El‑Sayed, Yasser S.× Kawano, Shuhei× Tanuma, Sei‑Ichi× Yamamoto, Yasuhiko |
|||||||
著者別表示 |
棟居, 聖一
× 棟居, 聖一× 原島, 愛× 武内 , 章彦× 土屋, 弘行× 山本, 靖彦 |
|||||||
提供者所属 | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | 金沢大学医薬保健研究域医学系 | |||||||
書誌情報 |
Oncology Letters 巻 15, 号 4, p. 4627-4634, 発行日 2018-04 |
|||||||
ISSN | ||||||||
収録物識別子タイプ | ISSN | |||||||
収録物識別子 | 1792-1074 | |||||||
DOI | ||||||||
関連タイプ | isIdenticalTo | |||||||
識別子タイプ | DOI | |||||||
関連識別子 | 10.3892/ol.2018.7902 | |||||||
出版者 | ||||||||
出版者 | Spandidos Publications | |||||||
抄録 | ||||||||
内容記述タイプ | Abstract | |||||||
内容記述 | Receptor for advanced glycation end-products (RAGE) is a pattern recognition receptor implicated in the pathogenesis of certain types of cancer. In the present study, papaverine was identified as a RAGE inhibitor using the conversion to small molecules through optimized‑peptide strategy drug design system. Papaverine significantly inhibited RAGE‑dependent nuclear factor κ‑B activation driven by high mobility group box‑1, a RAGE ligand. Using RAGE‑ or dominant‑negative RAGE‑expressing HT1080 human fibrosarcoma cells, the present study revealed that papaverine suppressed RAGE‑dependent cell proliferation and migration dose‑dependently. Furthermore, papaverine significantly inhibited cell invasion. The results of the present study suggested that papaverine could inhibit RAGE, and provided novel insights into the field of RAGE biology, particularly anticancer therapies. | |||||||
内容記述 | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | Embargo Period 6 months | |||||||
権利 | ||||||||
権利情報 | Copyright © 2018, Spandidos Publications. All rights reserved. | |||||||
著者版フラグ | ||||||||
出版タイプ | VoR | |||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
関連URI | ||||||||
識別子タイプ | URI | |||||||
関連識別子 | https://www.spandidos-publications.com/10.3892/ol.2018.7902 | |||||||
関連名称 | https://www.spandidos-publications.com/10.3892/ol.2018.7902 |