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ドナー細胞由来白血病発症機構への細胞外小胞の関与の検討
https://doi.org/10.24517/00054467
https://doi.org/10.24517/00054467d59bc1c4-79da-42c0-8906-3a09d0a5a724
名前 / ファイル | ライセンス | アクション |
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CA-PR-MUKAIDA-N-kaken 2019-6p.pdf (294.5 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2020-04-23 | |||||
タイトル | ||||||
タイトル | ドナー細胞由来白血病発症機構への細胞外小胞の関与の検討 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Elucidation of the roles of extracellular microsomes in donor cell-derived leukemia | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00054467 | |||||
ID登録タイプ | JaLC | |||||
著者 |
向田, 直史
× 向田, 直史 |
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著者別表示 |
Mukaida, Naofumi
× Mukaida, Naofumi |
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書誌情報 |
平成30(2018)年度 科学研究費補助金 挑戦的研究(萌芽) 研究成果報告書 en : 2018 Fiscal Year Final Research Report 巻 2017-06-30 - 2019-03-31, p. 6p., 発行日 2019-06-19 |
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出版者 | ||||||
出版者 | 金沢大学がん進展制御研究所 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | BCR-ABL陽性慢性骨髄性白血病(CML)マウスに対して、X線照射・骨髄移植を行うと、核型異常を示すドナー細胞由来顆粒球の出現と重篤な貧血からなる骨髄異形成症候群を呈する、ドナー細胞由来白血病(DCL)を発症した。レシピエントCML細胞由来の細胞外小胞中の大量の二本鎖DNAが、ドナー細胞に水平伝播し、ドナー細胞内でSTING経路を介してインターフェロン経路が活性化され、ドナー由来の造血幹/前駆細胞のvitroでの複製能が低下することが明らかになった。さらに、CML発症マウスに対して、X線照射後に、STING欠損マウス由来の骨髄細胞を移植しても、DCL様の病態の出現が認められなかった。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Mice with BCR-ABL-positive chronic myelogenous leukemia (CML) developed donor cell-derived leukemia (DCL), myelodysplastic syndrome with donor cell-derived granulocytes with aberrant nuclear morphology and severe anemia, when normal donor cells were transplanted after irradiation. Recipient leukemia cell-derived extravesicles abundantly contain double-stranded DNA (dsDNA), which was horizontally transmitted into donor cells. In vitro studies demonstrated that dsDNA activated STING and subsequently interferon pathways in donor cells, thereby inhibiting replication capacity of donor hematopoietic stem/progenitor cells. Moreover, CML mice did not develop DCL when they received STING-deficient mouse-derived bone marrow cells after irradiation. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:17K19681, 研究期間(年度):2017-06-30 - 2019-03-31 | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=30182067 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=30182067 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K19681/ | |||||
関連名称 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K19681/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K19681/17K19681seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K19681/17K19681seika/ |