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肝細胞周期調節因子の肝糖脂質代謝における役割
https://doi.org/10.24517/00055336
https://doi.org/10.24517/00055336ff17baae-2287-43fa-ba5c-37b95b1d5f31
名前 / ファイル | ライセンス | アクション |
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FR-PR-INOUE-H-kaken 2011-4p.pdf (320.4 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2019-09-05 | |||||
タイトル | ||||||
タイトル | 肝細胞周期調節因子の肝糖脂質代謝における役割 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Investigation of the role of cell-cycle regulatory mechanism in hepatic glucose metabolism | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00055336 | |||||
ID登録タイプ | JaLC | |||||
著者 |
井上, 啓
× 井上, 啓 |
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著者別表示 |
Inoue, Hiroshi
× Inoue, Hiroshi |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学新学術創成研究機構 | |||||
書誌情報 |
平成22(2010)年度 科学研究費補助金 若手研究(B) 研究成果報告書 en : 2010 Fiscal Year Final Research Report 巻 2009 – 2010, p. 4p., 発行日 2011-04-01 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Cyclin D1は、細胞周期調節のみならず、様々な転写因子の活性を制御している。肝臓Cyclin D1の遺伝子および蛋白発現は、絶食に伴い減少し、食事摂取後に増加した。培養肝細胞を用いた糖新生酵素プロモーター解析では、Cyclin D1の遺伝子導入により肝糖新生酵素遺伝子発現プロモーター活性が、減少した。これらの結果は、肝臓Cyclin D1が糖代謝制御に何らかの役割を果たす可能性を示している。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Cyclin D1 is known to regulate not only cell-cycle but also activity of various transcription factors. Through this investigation, we have uncoverd an alteration in hepatic cyclin D1 expression by fasting and refeeding. Fasting reduced the expression of cyclin D1 gene and protein and refeeding increased. We have also clarified that cyclin D1 suppressed the promoter activity of gluconeogenic gene in H42E hepatoma cell. These results suggest that hepatic cyclin D1 would plays a certain role in the regulation of glucose metabolism. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:研究課題「肝細胞周期調節因子の肝糖脂質代謝における役割」課題番号21790868 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21790868/21790868seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=50397832 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=50397832 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790868/ | |||||
関連名称 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790868/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21790868/21790868seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21790868/21790868seika/ |