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腎疾患におけるリゾリン脂質産生酵素(ATX, PS-PLA1)の臨床的意義の解明
https://doi.org/10.24517/00055362
https://doi.org/10.24517/0005536244631203-a4e5-4d4b-8830-2eb91ea71e28
名前 / ファイル | ライセンス | アクション |
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HE-PR-SHIMIZU-M-kaken 2017-5p.pdf (344.5 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2019-09-06 | |||||
タイトル | ||||||
タイトル | 腎疾患におけるリゾリン脂質産生酵素(ATX, PS-PLA1)の臨床的意義の解明 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Clinical significance of serum autotaxin(ATX) and phosphatidylserine-specific phospholipase A1 (PS-PLA1) levels in human kidney disease | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00055362 | |||||
ID登録タイプ | JaLC | |||||
著者別表示 |
Shimizu, Miho
× Shimizu, Miho |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学保健管理センター | |||||
書誌情報 |
平成28(2016)年度 科学研究費補助金 基盤研究(C) 研究成果報告書 en : 2016 Fiscal Year Final Research Report 巻 2014-04-01 - 2017-03-31, p. 5p., 発行日 2017-06-08 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 本研究では、生理活性リゾリン脂質のうち、リゾホスファチジン酸の産生酵素であるオートタキシン(autotaxin: ATX)の糖尿病性腎症における臨床的意義を検討した。糖尿病性腎症合併を組織診断された2型糖尿病 38例を対象とした解析にて、腎生検時の血清ATX濃度は尿蛋白量と正相関を示した。また、対象を血清ATX濃度の中央値で層別化したところ、血清ATX濃度高値群ではびまん性病変、結節性病変、細動脈硝子化が進展していたが、腎複合イベント(透析導入または推算糸球体濾過量の50%低下)発症率には差を認めなかった。以上の成績を、Intern Med誌(2016; 55: 215-221)に報告した. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We evaluated the relationships between the serum autotaxin (ATX) levels and the clinical and pathological parameters, as well as the long-term renal outcome, in type 2 diabetic patients with biopsy-proven diabetic nephropathy. In this retrospective study, serum samples were collected from 38 Japanese type 2 diabetic patients with biopsy-proven diabetic nephropathy at the time of renal biopsy. A multivariate linear regression analysis revealed the urinary protein excretion to be independently associated with the serum ATX levels. In addition, patients with serum ATX levels above the median showed more advanced diffuse lesions, nodular lesions and arteriolar hyalinosis compared to those with serum ATX levels below the median. However, high serum ATX levels were not associated with renal composite events (need for dialysis or a 50% decline in the estimated glomerular filtration rate from baseline). Parts of this study were published in the Internal Medicine (2016; 55: 215-221). | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:26460644, 研究期間(年度):2014-04-01 - 2017-03-31 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:「腎疾患におけるリゾリン脂質産生酵素(ATX, PS-PLA1)の臨床的意義の解明」研究成果報告書 課題番号26460644 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26460644/26460644seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=10547136 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=10547136 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26460644/ | |||||
関連名称 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26460644/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26460644/26460644seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26460644/26460644seika/ |