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ヒト皮下脂肪由来エリート間葉系幹細胞の同定とその保有数に影響を与える因子の検証
https://doi.org/10.24517/00056160
https://doi.org/10.24517/00056160c471d164-fd11-4656-b0f1-577e927ca576
名前 / ファイル | ライセンス | アクション |
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HO-PR-INOUE-O-kaken 2018-4p.pdf (394.0 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2019-11-22 | |||||
タイトル | ||||||
タイトル | ヒト皮下脂肪由来エリート間葉系幹細胞の同定とその保有数に影響を与える因子の検証 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Identification and validation of the angiogenic adipose-derived stem cells among patients with cardiovasciular diseases | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00056160 | |||||
ID登録タイプ | JaLC | |||||
著者 |
井上, 己音
× 井上, 己音 |
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著者別表示 |
Inoue, Oto
× Inoue, Oto |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学附属病院検査部 | |||||
書誌情報 |
平成29(2017)年度 科学研究費補助金 研究活動スタート支援 研究成果報告書 en : 2017 Fiscal Year Final Research Report 巻 2016-08-26 - 2018-03-31, p. 4p., 発行日 2018-05-25 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 脂肪組織由来間葉系幹細胞ADRCは、重症心臓血管病への新規治療として注目されているが、患者感で効果がばらつくことが問題点である。我々は、20名程度の心臓血管病を有する症例からADRCを分離し、その血管新生能について検討を行った。患者由来ADRCはインスリン抵抗性-脂肪慢性炎症-CD271陽性サブセットの減少、という大まかな流れの中で劣化するという知見を得た。同定されたCD271陽性ADRCは、ADRC自体の増殖能・増殖因子発現量・移植モデルにおける足壊疽治療効果能と有意に相関しており、幹細胞治療の効果に大きな影響を与えるサブセットと考え、解析を進めている。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Adipose-derived stem cells (ADSCs) have been emerged as an attractive option for regenerative therapy. ADSCs are composed of various subsets and the CD271+ subset is reported to be more primitive and proliferative. ADSCs were isolated from subcutaneous adipose tissue of 20 patients undergoing elective cardiac surgery. The percentages of CD271+ subset in CD45-CD34+ ADSCs were measured by flowcytometer. According to the CD271 frequency, ADSCs samples were divided into two groups (“high” and “low” groups). Nude mice were subjected to hindlimb ischemia and 1 million of ADSCs) were injected into the ischemic muscles. At day 14, neovascularization was evaluated by laser Doppler analysis and histological analysis using fluorescent-labeled lectin perfusion in duplicate. Intramuscular injection of ADSCs of the “high” group demonstrated enhanced neovascularization compared to the “low” group in laser Doppler analysis and also in histological analysis. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:16H06828, 研究期間(年度):2016-08-26 - 2018-03-31 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:研究課題「ヒト皮下脂肪由来エリート間葉系幹細胞の同定とその保有数に影響を与える因子の検証」課題番号16H06828 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16H06828/16H06828seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=00781147 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=00781147 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H06828/ | |||||
関連名称 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H06828/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16H06828/16H06828seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16H06828/16H06828seika/ |