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インデックスリンク
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ヘムオキシゲナーゼー1が造血幹細胞移植後治療成績におよぼす効果と新規治療戦略
https://doi.org/10.24517/00057428
https://doi.org/10.24517/000574287dd5be24-9ecf-4ed5-b25e-860aaab40892
名前 / ファイル | ライセンス | アクション |
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ME-PR-MORISHITA-E-kaken 2021-22p.pdf (354.0 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2022-02-04 | |||||
タイトル | ||||||
タイトル | ヘムオキシゲナーゼー1が造血幹細胞移植後治療成績におよぼす効果と新規治療戦略 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Effect of heme oxygenase-1 on treatment results after hematopoietic stem cell transplantation and new therapeutic strategies | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00057428 | |||||
ID登録タイプ | JaLC | |||||
著者 |
森下, 英理子
× 森下, 英理子 |
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著者別表示 |
Morishita, Eriko
× Morishita, Eriko |
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書誌情報 |
令和2(2020)年度 科学研究費補助金 基盤研究(C) 研究成果報告書 en : 2020 Fiscal Year Final Research Report 巻 2018-04-01 - 2021-03-31, p. 22p., 発行日 2021-06-07 |
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出版者 | ||||||
出版者 | 金沢大学医薬保健研究域保健学系 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 同種造血幹細胞移植(SCT)後の移植片対宿主病、血栓性微小血管障害症などの致死的な合併症は、依然として克服すべき障害である。今回、抗血栓作用や免疫調整にかかわる因子発現に影響する遺伝子一塩基多型(SNP)とSCT後転帰の関連性を、日本骨髄バンクの協力を得て国内の非血縁者間SCT症例(ドナーと移植患者約600組)を対象として解析した。結果として、ドナーHO-1 SNP rs2071746 A/AまたはA/T型、ドナーUNC93B1 rs308328 C/C型は移植後合併症を抑え生存率改善に寄与、患者ADAMTS-13 rs2285489 C/C型は無病生存率に悪影響する可能性が考えられた。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Life-threatening complications associated with allogeneic hematopoietic stem cell transplantation (SCT),such as severe infection, graft-versus-host disease (GVHD), and thrombotic microangiopathy, remain obstacles to overcome. We investigated the influence of the HO-1 single-nucleotide polymorphism (SNP) rs2071746 (-413A>T), ADAMTS-13 SNP rs2285489 (C>T), UNC-93 homolog B1 SNP rs308328 (T>C) on transplant outcomes in a cohort of about 600 patients undergoing unrelated HLA-matched bone marrow transplantation (BMT) for hematologic malignancies through the Japan Marrow Donor Program. As a result, the donor HO-1 A/A or A/T genotype and donor UNC93B1 C/C genotype were associated with a better overall survival. On the other hand, the recipient ADAMTS13 C/C genotype was associated with an increased relapse rate, resulting in a lower disease-free survival rate in the patients with a recipient C/C genotype. |
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内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:18K07442, 研究期間(年度):2018-04-01 - 2021-03-31 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:「ヘムオキシゲナーゼー1が造血幹細胞移植後治療成績におよぼす効果と新規治療戦略」研究成果報告書 課題番号18K07442 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K07442/18K07442seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=50251921 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=50251921 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K07442/ | |||||
関連名称 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K07442/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K07442/18K07442seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K07442/18K07442seika/ |