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Glyoxalase1遺伝子多型に基づく統合失調症の病態解明と新規治療薬の創出
https://doi.org/10.24517/00057625
https://doi.org/10.24517/000576250c7a5bed-8789-4da6-9f4a-44523c8b4311
名前 / ファイル | ライセンス | アクション |
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ME-PR-HARASHIMA-A-kaken 2021-9p.pdf (125.3 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2022-02-10 | |||||
タイトル | ||||||
タイトル | Glyoxalase1遺伝子多型に基づく統合失調症の病態解明と新規治療薬の創出 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Understanding of pathophysiological mechanisms and development of the treatment of schizophrenia based on novel gene polymorphisms of glyoxalase 1. | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00057625 | |||||
ID登録タイプ | JaLC | |||||
著者 |
原島, 愛
× 原島, 愛 |
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著者別表示 |
Harashima, Ai
× Harashima, Ai |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域医学系 | |||||
書誌情報 |
令和2(2020)年度 科学研究費補助金 基盤研究(C) 研究成果報告書 en : 2020 Fiscal Year Final Research Report 巻 2018-04-01 - 2021-03-31, p. 9p., 発行日 2021-05-10 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Glyoxalase 1(GLO1)はこれまで統合失調症との関連が示唆されていたが、詳細は不明であった。本研究では、研究代表者らが新たに見出したGLO1プロモーター領域内に存在する遺伝子多型が統合失調症の病態形成に関与していることが、ヒト臨床検体だけでなく疾患iPS細胞を用いた検討でも示唆された。加えて、統合失調症の病態形成への関与が示唆される遺伝子変異をGLO1プロモーター領域内で新たに見出すことに成功した。この遺伝子変異は統合失調症特異的であり、この遺伝子変異に着目することで、統合失調症の病態形成の全貌を明らかにできる可能性がある。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Glyoxalase 1 (GLO1) has been known to be associated with schizophrenia. However, the mechanism remains unknown. In this study, we revealed that novel gene polymorphisms in the human GLO1 promoter were involved in the pathogenesis of schizophrenia using human samples as well as iPS cells derived from the patients. In addition, we identified a novel gene mutation in human GLO1 promoter region in the patients with schizophrenia. The gene mutation was found to be specific to schizophrenia. These findings suggest that GLO1 gene could be a target for the treatment and prophylaxis of schizophrenia. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:18K07551, 研究期間(年度):2018-04-01 - 2021-03-31 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:「Glyoxalase1遺伝子多型に基づく統合失調症の病態解明と新規治療薬の創出」研究成果報告書 課題番号18K07551 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K07551/18K07551seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=50705522 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=50705522 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K07551/ | |||||
関連名称 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K07551/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K07551/18K07551seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K07551/18K07551seika/ |