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小動物SPECT・PET同時測定法における物理現象の解明と定量評価法の確立
https://doi.org/10.24517/00057987
https://doi.org/10.24517/00057987d6f1a15d-6930-43fa-a4fb-6176aebfb55b
名前 / ファイル | ライセンス | アクション |
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ME-PR-SHIBUTANI-T-kaken 2021-9p.pdf (171.4 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2022-02-18 | |||||
タイトル | ||||||
タイトル | 小動物SPECT・PET同時測定法における物理現象の解明と定量評価法の確立 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Formulation of quantitative method and clarification of physical phenomenon for simultaneous small-animal SPECT and PET system | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00057987 | |||||
ID登録タイプ | JaLC | |||||
著者 |
澁谷, 孝行
× 澁谷, 孝行 |
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著者別表示 |
Shibutani, Takayuki
× Shibutani, Takayuki |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域保健学系 | |||||
書誌情報 |
令和2(2020)年度 科学研究費補助金 若手研究 研究成果報告書 en : 2020 Fiscal Year Final Research Report 巻 2018-04-01 - 2021-03-31, p. 9p., 発行日 2021-06-18 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 小動物研究の中で虚血性心疾患の評価に重要な心筋バイアビリティは,別時相で収集されるため,小動物の時相差に伴う生理状態の違いが定量誤差となり,病態と分子情報のミスマッチが生じていた。その問題を解決するために,本研究ではTc-99m心筋血流とF-18の心筋糖代謝情報を対象に本邦初導入された小動物用SPECT・PET同時収集システムを用いて複数分子同時収集における心筋バイアビリティ定量評価法を開発した。 小動物を模擬したファントムを新たに開発し,複数分子同時収集で問題となるクロストークによる画質劣化と部分容積効果による定量値の過小評価を改善するための補正技術を確立させた。 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Myocardial viability evaluation which is important for ischemic heart disease in small animal studies is acquired in different time phases, and it was a mismatch between the pathological condition and the molecular information due to the quantitative error caused by the difference in physiological state caused by the time phase difference of small animals. To resolve this problem, we developed a quantitative evaluation method of myocardial viability in simultaneous acquisition of multiple molecules for Tc-99m myocardial blood flow and F-18 myocardial glucose metabolism using the small animal SPECT/PET simultaneous acquisition system introduced for the first time in Japan. A phantom simulating a small animal was newly developed, and a correction technique was established to improve image quality due to crosstalk and underestimation of quantitative values caused by partial volume effect which are problems in simultaneous acquisition of multiple molecules. |
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内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:18K15628, 研究期間(年度):2018-04-01 - 2021-03-31 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:「小動物SPECT・PET同時測定法における物理現象の解明と定量評価法の確立」研究成果報告書 課題番号18K15628 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K15628/18K15628seika/ )を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=80762509 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=80762509 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K15628/ | |||||
関連名称 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K15628/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K15628/18K15628seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K15628/18K15628seika/ |