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全身性強皮症におけるEffector B細胞の役割についての検討
https://doi.org/10.24517/00057998
https://doi.org/10.24517/00057998fbf25fc7-c05f-443b-94b7-cb93c9c8abfe
名前 / ファイル | ライセンス | アクション |
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ME-PR-TAKEHARA-K-kaken 2020-6p.pdf (347.5 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2021-04-26 | |||||
タイトル | ||||||
タイトル | 全身性強皮症におけるEffector B細胞の役割についての検討 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | The role of Effector B cell in Systemic Sclerosis | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00057998 | |||||
ID登録タイプ | JaLC | |||||
著者 |
竹原, 和彦
× 竹原, 和彦 |
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著者別表示 |
Takehara, Kazuhiko
× Takehara, Kazuhiko |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域医学系 | |||||
書誌情報 |
令和1(2019)年度 科学研究費補助金 基盤研究(C) 研究成果報告書 en : 2019 Fiscal Year Final Research Report 巻 2017-04-01 - 2020-03-31, p. 6p., 発行日 2020-04-17 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 全身性強皮症は皮膚・内臓諸臓器の線維化を来す自己免疫疾患で、その病態形成にB細胞が強く関与している。PBMCを採取し、CpG、PMA、Ionomycin存在下で5時間培養し、細胞IL-6染色を行いFACSにてIL-6産生Effector B細胞を測定する系を確立した。また、強皮症患者におけるIL-6産生B細胞の頻度を解析したところ、健常人と比べ、強皮症で有意にIL-6産生B細胞が増加していた。さらにIL-6産生B細胞は強皮症の皮膚硬化の重症度を反映していた。さらに抗BAFF抗体投与によりにIL-6産生Effector B細胞が低下することが明らかとなった。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Systemic sclerosis (SSc) is an autoimmune disease characterized by skin and lung fibrosis. B cells play an important role in SSc pathogenesis. The blood levels of IL-6 producing effector B cells and IL-10 producing regulatory B cells were measured in 29 patients with SSc and 20 healthy subjects by FACS. The frequency of IL-6 producing effector B cells in blood was significantly elevated in patients with SSc than that in healthy controls. In contrast, the frequency of IL-10 producing regulatory B cells in blood was significantly decreased in patients with SSc than in healthy controls. Furthermore, the frequency of IL-6 producing effector B cells positively correlated with the extent of skin fibrosis in SSc patients.The result suggested that the dysregulation of effector and regulatory B cell balance contributes to SSc pathogenesis. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:17K10232, 研究期間(年度):2017-04-01 - 2020-03-31 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:「全身性強皮症におけるEffector B細胞の役割についての検討」研究成果報告書 課題番号17K10232 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K10232/17K10232seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=50142253 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=50142253 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K10232/ | |||||
関連名称 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K10232/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K10232/17K10232seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K10232/17K10232seika/ |