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子宮筋腫に対する新規治療戦略の開発
https://doi.org/10.24517/00059347
https://doi.org/10.24517/00059347ec2908e6-ffe3-4420-8d90-1b94ee952377
名前 / ファイル | ライセンス | アクション |
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HO-PR-ONO-M-kaken 2019-5p.pdf (129.5 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2020-10-01 | |||||
タイトル | ||||||
タイトル | 子宮筋腫に対する新規治療戦略の開発 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Development of novel therapeutic strategies for uterine leiomyoma | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00059347 | |||||
ID登録タイプ | JaLC | |||||
著者別表示 |
Ono, Masanori
× Ono, Masanori |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学附属病院 | |||||
書誌情報 |
平成30(2018)年度 科学研究費補助金 基盤研究(C) 研究成果報告書 en : 2018 Fiscal Year Final Research Report 巻 2016-04-01 – 2019-03-31, p. 5p., 発行日 2019-06-04 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 性ステロイドが、性ステロイド受容体陽性の子宮筋あるいは子宮筋腫細胞を活性化させ、活性化された細胞からのWNT分泌により、子宮筋腫幹細胞のWNT/β-カテニンシグナルを活性化することを示した。これにより子宮筋腫幹細胞が増殖することを示した。また,細胞表面抗原であるCD34およびCD49bの発現に基づいた子宮筋腫細胞集団すなわちCD34+/CD49b+の子宮筋腫幹細胞、CD34+/CD49b-の中間細胞、CD34-/CD49b-の成熟子宮筋腫細胞に分けられることを報告した。さらに子宮筋腫の発育にIGF2とInsulin Receptor Aのシグナルが関与することを示した。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Tissue-specific stem cells constitute a subset of cells residing in normal adult tissues. Estrogen and progesterone stimulate the growth of leiomyomas. Estrogen, together with its receptor ERα, enables progesterone action via induction of progesterone receptor expression. Progesterone induces the growth of leiomyoma by regulation of a set of key genes that control proliferation and apoptosis.The WNT/β-catenin pathway comprises a key component of this signaling system. The majority of medical treatments currently available for leiomyoma works by inhibiting estrogen or progesterone production or action, but tumors tend to regrow once treatment is stopped. We showed that uterine leiomyoma stem cells involve IGF2 and Insulin Receptor A. Targeting stem cells and their paracrine interactions with more differentiated cell populations within leiomyoma may lead to the development of more effective therapeutics for uterine leiomyoma. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:16K11107, 研究期間(年度):2016-04-01 – 2019-03-31 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:研究課題「子宮筋腫に対する新規治療戦略の開発」課題番号16K11107 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-16K11107/16K11107seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/ja/search/?kw=70348712 | |||||
関連名称 | https://kaken.nii.ac.jp/ja/search/?kw=70348712 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-16K11107/ | |||||
関連名称 | https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-16K11107/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-16K11107/16K11107seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-16K11107/16K11107seika/ |