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口腔扁平上皮癌におけるClaudin機能発現が浸潤・転移に及ぼす影響
https://doi.org/10.24517/00059692
https://doi.org/10.24517/00059692b3b75208-95db-4c6b-b975-26a83f7dbf32
名前 / ファイル | ライセンス | アクション |
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HO-PR-YOSHIZAWA-K-kaken 2014-4p.pdf (268.0 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2020-10-19 | |||||
タイトル | ||||||
タイトル | 口腔扁平上皮癌におけるClaudin機能発現が浸潤・転移に及ぼす影響 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Suppressive effect of invasion and metastasis of oral squamous cell carcinoma by Claudin expression | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00059692 | |||||
ID登録タイプ | JaLC | |||||
著者 |
吉澤, 邦夫
× 吉澤, 邦夫 |
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著者別表示 |
Yoshizawa, Kunio
× Yoshizawa, Kunio |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学附属病院 | |||||
書誌情報 |
平成25(2013)年度 科学研究費補助金 若手研究(B) 研究成果報告書 en : 2013 Fiscal Year Final Research Report 巻 2012-04-01 – 2014-03-31, p. 4p., 発行日 2014-05-23 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 免疫組織化学染色において口腔扁平上皮癌におけるClaudin-7陽性発現は、67症例中35症例であり、52.2%であった。臨床病理学的因子との関連では、腫瘍の大きさ、リンパ節転移と浸潤様式に逆相関を示した。また、さらに浸潤様式山本・小浜分類別に口腔扁平上皮癌細胞株を用いて、タンパク発現とmRNA発現をWestern blotting法とRT-PCR法にて検索すると、浸潤様式が最も高く浸潤・転移能が最も強い4D型では、他の浸潤様式に比べてClaudin-7発現は減弱していることが判明した。これらのことからClaudin-7は浸潤・転移に密接に関連し、発現現弱は予後不良因子であることが示唆された。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Using immunohistochemical techniques to examine the expression levels of claudin-7 in 67 cases of OSCC, claudin-7 expression was detected in 35 (52.2%) of the 67 cases. Moreover, six cell lines with various invasive properties were investigated in vitro to compare mRNA and protein levels of claudin-7 using reverse transcription-polymerase chain reaction (RT-PCR) and the western blotting method. Decreased claudin-7 expression correlated significantly with T-category (p<0.05), lymph node metastasis (p<0.01), and mode of invasion (p<0.001). Patients with positive claudin-7 expression had a significantly better prognosis (p<0.05). Claudin-7 protein and mRNA levels were lower in the HOC313 and TSU cells, which have higher invasive potentials compared with other cell lines. These results suggest that loss of claudin-7 expression is associated closely with invasion and lymph metastasis and is an unfavorable prognostic factor in patients with OSCC. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:24792194, 研究期間(年度):2012-04-01 – 2014-03-31 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:「口腔扁平上皮癌におけるClaudin機能発現が浸潤・転移に及ぼす影響」研究成果報告書 課題番号24792194 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-24792194/24792194seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/ja/search/?kw=60452108 | |||||
関連名称 | https://kaken.nii.ac.jp/ja/search/?kw=60452108 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-24792194 | |||||
関連名称 | https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-24792194 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-24792194/24792194seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-24792194/24792194seika/ |