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脂質代謝を制御する酵素活性の新たな測定法の開発とその臨床応用
https://doi.org/10.24517/00059784
https://doi.org/10.24517/000597848507d55e-8b9c-4bfa-8620-2c01cb7a6c6b
名前 / ファイル | ライセンス | アクション |
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ME-PR-KOBAYASHI-J-kaken 2011-4p.pdf (367.4 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2020-11-26 | |||||
タイトル | ||||||
タイトル | 脂質代謝を制御する酵素活性の新たな測定法の開発とその臨床応用 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Novel method of measuring activities of enzymes involved in lipid metabolism | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00059784 | |||||
ID登録タイプ | JaLC | |||||
著者 |
小林, 淳二
× 小林, 淳二 |
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著者別表示 |
Kobayashi, Junji
× Kobayashi, Junji |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域医学系 | |||||
書誌情報 |
平成22(2010)年度 科学研究費補助金 基盤研究(C) 研究成果報告書 en : 2010 Fiscal Year Final Research Report 巻 2008 – 2010, p. 4p., 発行日 2011-05-11 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 脂質代謝を制御する酵素であるLPLとHTGLの活性を測定する簡便な系を確立し、その臨床意義を検討した。LPL活性はTG、RLP-TG,sdLDLと逆相関、HDL-Cと正相関したしたが、ANGPTL3と相関なし。一方、HTGL活性はTG、RLP-TG、sdLDLと相関せず、HDL-C、ANGPTL3と逆相関した。ANGPTL3によるHTGL活性抑制は見られなかった。以上から、ANGPTL3とHTGL両者の上流にそれらの制御にかかわる因子が存在し、それぞれを逆方向に制御する可能性が示唆された。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We have established a simple and reliable system for measuring LPL and HTGL activities in post-heparin plasma and investigated clinical significance of measuring those activities. LPL activities showed inverse relations with TG, RLP-TG and sdLDL and positive relations with HDL-C but had no relation with ANGPTL3. HTGL activities showed no relation with TG, RLP-TG and sdLDL but had inverse relations with HDL-C and ANGPTL3. In vitro experiment showed that ANGPTL3 did not inhibit HTGL activities at all, suggesting unidentified molecule may regulate ANGPTL3 and HTGL each other in opposite directions. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:20590560, 研究期間(年度):2008 – 2010 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:研究課題「脂質代謝を制御する酵素活性の新たな測定法の開発とその臨床応用」課題番号20590560 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-20590560/20590560seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/ja/search/?kw=60302577 | |||||
関連名称 | https://kaken.nii.ac.jp/ja/search/?kw=60302577 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-20590560/ | |||||
関連名称 | https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-20590560/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-20590560/20590560seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-20590560/20590560seika/ |