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Lung Macrophages: Multifunctional Regulator Cells for Metastatic Cells
https://doi.org/10.24517/00061536
https://doi.org/10.24517/000615361e14d99f-9fd6-4169-bdee-2f0a904baa30
名前 / ファイル | ライセンス | アクション |
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CA-PR-MUKAIDA-N-20-00116.pdf (1.5 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-03-26 | |||||
タイトル | ||||||
タイトル | Lung Macrophages: Multifunctional Regulator Cells for Metastatic Cells | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00061536 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Mukaida, Naofumi
× Mukaida, Naofumi× Nosaka, Takuto× Nakamoto, Yasunari× Baba, Tomohisa |
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著者別表示 |
向田, 直史
× 向田, 直史× 馬場, 智久× 中本, 安成 |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学がん進展制御研究所 | |||||
書誌情報 |
International Journal of Molecular Sciences 巻 20, 号 1, p. 116, 発行日 2019-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1661-6596 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3390/ijms20010116 | |||||
出版者 | ||||||
出版者 | MDPI AG | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Metastasis is responsible for most of the cancer-associated deaths and proceeds through multiple steps. Several lines of evidence have established an indispensable involvement of macrophages present at the primary tumor sites in various steps of metastasis, from primary tumor growth to its intravasation into circulation. The lungs encompass a large, dense vascular area and, therefore, are vulnerable to metastasis, particularly, hematogenous ones arising from various types of neoplasms. Lung tissues constitutively contain several types of tissue-resident macrophages and circulating monocytes to counteract potentially harmful exogenous materials, which directly reach through the airway. Recent advances have provided an insight into the ontogenetic, phenotypic, and functional heterogeneity of these lung macrophage and monocyte populations, under resting and inflammatory conditions. In this review, we discuss the ontogeny, trafficking dynamics, and functions of these pulmonary macrophages and monocytes and their potential roles in lung metastasis and measures to combat lung metastasis by targeting these populations. © 2018 by the authors. Licensee MDPI, Basel, Switzerland. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acknowledgments: This work is supported partially by Research Program on the Innovative Development and Application for New Drugs for Hepatitis B (17fk0310116h0001) from the Japan Agency for Medical Research and Development (AMED) (N.M., Y.N.) and Extramural Collaborative Research Grant of Cancer Research Institute, Kanazawa University (N.M., Y.N.). | |||||
権利 | ||||||
権利情報 | Copyright © 2018 by the authors. Licensee MDPI, Basel, Switzerland. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.mdpi.com/1422-0067/20/1/116 | |||||
関連名称 | https://www.mdpi.com/1422-0067/20/1/116 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.mdpi.com/journal/ijms | |||||
関連名称 | https://www.mdpi.com/journal/ijms |