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The effect of 17s-estradiol administration on cutaneous wound healing in 24-week ovariectomized female mice.
https://doi.org/10.24517/00061588
https://doi.org/10.24517/000615888dd39825-4f44-45ff-b44a-7c0810cd1ead
名前 / ファイル | ライセンス | アクション |
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ME-PR-NAKATANI-T-2014_1-8.pdf (384.9 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-04-09 | |||||
タイトル | ||||||
タイトル | The effect of 17s-estradiol administration on cutaneous wound healing in 24-week ovariectomized female mice. | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00061588 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Mukai, Kanae
× Mukai, Kanae× Komatsu, Emi× Nakajima, Yukari× Urai, Tamae× Nasruddin× Sugama, Junko× Nakatani, Toshio |
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著者別表示 |
向井, 加奈恵
× 向井, 加奈恵× 中島, 由加里× 須釜, 淳子× 中谷, 壽男 |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域保健学系 | |||||
書誌情報 |
Journal of Hormones 巻 2014, 号 234632, p. 1-8, 発行日 2014-12-07 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2356-7449 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1371/journal.pone.0115564 | |||||
出版者 | ||||||
出版者 | Hindawi | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Cutaneous wound healing is delayed by protein malnutrition (PM). On the other hand, estrogen promotes cutaneous wound healing by its anti-inflammatory and cell proliferation effects. Therefore, we hypothesized that estrogen administration in protein-malnourished ovariectomized (OVX) female mice might improve the inflammatory response and promote cutaneous wound healing as well as normal nutrition. To test this hypothesis, we used full-thickness excisional wounds in Control SHAM, PM SHAM, PM OVX and PM OVX+17β-estradiol mice. The Control diet included 200 g/kg protein and the PM diet included 30 g/kg protein. The ratio of wound area in the Control SHAM group was significantly smaller than those in the three PM groups. In addition, microscopic findings also showed that the ratio of collagen fibers, the ratio of myofibroblasts and the number of new blood vessels in the Control SHAM group were significantly greater than those in the three PM groups. However, the number of Ym1-positive cells as an anti-inflammatory M2-like macrophage marker in the PM OVX+17β-estradiol group was significantly higher than those in the other three groups. These results indicate that the appearance of anti-inflammatory M2-like macrophages was promoted by estrogen administration; however, it could not promote cutaneous wound healing upon a low-protein diet. Therefore, it may be confirmed that nutrition is more important for promoting cutaneous wound healing than estrogen administration. | |||||
権利 | ||||||
権利情報 | Copyright: © 2014 Mukai et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0115564 | |||||
関連名称 | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0115564 |