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Extravasated Platelet Aggregation in Liver Zone 3 Is Associated With Thrombocytopenia and Deterioration of Graft Function After Living-Donor Liver Transplant
https://doi.org/10.24517/00061860
https://doi.org/10.24517/000618601a7fbab8-fc31-42c3-8780-63ece4d6e746
名前 / ファイル | ライセンス | アクション |
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ME-PR-NAKANUMA-S-556-562.pdf (414.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-04-26 | |||||
タイトル | ||||||
タイトル | Extravasated Platelet Aggregation in Liver Zone 3 Is Associated With Thrombocytopenia and Deterioration of Graft Function After Living-Donor Liver Transplant | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00061860 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Nakanuma, Shinichi
× Nakanuma, Shinichi× Miyashita, Tomoharu× Hayashi, Hironori× Tajima, Hidehiro× Takamura, Hiroyuki× Makino, Isamu× Oyama, Katsunobu× Nakagawara, Hisatoshi× Fushida, Sachio× Ohta, Tetsuo |
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著者別表示 |
中沼, 伸一
× 中沼, 伸一× 宮下, 知治× 高村, 博之× 林, 泰寛× 田島, 秀浩× 牧野, 勇× 尾山, 勝信× 中川原, 寿俊× 伏田, 幸夫× 太田, 哲生 |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学附属病院肝胆膵・移植外科 | |||||
書誌情報 |
Experimental and Clinical Transplantation 巻 13, 号 6, p. 556-562, 発行日 2015-12 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1304-0855 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.6002/ect.2015.0063 | |||||
PMID | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 26643676 | |||||
出版者 | ||||||
出版者 | Baskent University, Publishers / The Middle East Society for Organ Transplantation (MESOT) | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Objectives: Continuous thrombocytopenia after liver transplant is associated with a less favorable prognosis, but this pathogenesis remains unclear. We focused on the consumption of platelets in the allograft. We assessed platelet consumption in allografts, and evaluated the pathology of platelet aggregation in an allograft tissue and its involve-ment in clinical outcomes. Materials and Methods: We took biopsy specimens from 20 patients. To examine the localization of platelet aggregation, CD42b was assayed immuno-histochemically, and its level of expression correlated with clinical data and outcomes. Results: Platelet aggregation in zone 3 was 70%, compared with 30% in zone 1 and 50% in zone 2. Platelets were found mainly as extravasated platelet aggregates in local microenvironments. Patients were stratified according to the extent of extravasated platelet aggregates in zone 3 into extravasated platelet aggregate-negative and -positive groups. Graft weight/recipient body weight ratio with the extravasated platelet aggregate-positive group was significantly lower than that of the extravasated platelet aggregate-negative group. Platelet count after surgery was lower, while total bilirubin and prothrombin time/international normalized ratio were higher in the extravasated platelet aggregate-positive than they were in the extravasated platelet aggregate-negative group. Conclusions: Extravasated platelet aggregates in the zone 3 of allograft tissue cause the consumption of platelets and continuous thrombocytopenia after transplant, and may be the clinical marker for deterioration of graft function. Platelet activation and degranulation following the release by platelets of some negative regulators may be involved partially in liver damage. |
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権利 | ||||||
権利情報 | Copyright © Baskent University | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.ectrx.org/home | |||||
関連名称 | http://www.ectrx.org/home | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.ectrx.org/archive/2015/13/6/0 | |||||
関連名称 | http://www.ectrx.org/archive/2015/13/6/0 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.ectrx.org/forms/ectrxcontentshow.php?year=2015&volume=13&issue=6&supplement=0&makale_no=0&spage_number=556&content_type=FULL%20TEXT | |||||
関連名称 | http://www.ectrx.org/forms/ectrxcontentshow.php?year=2015&volume=13&issue=6&supplement=0&makale_no=0&spage_number=556&content_type=FULL%20TEXT |