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Selenium-binding lactoferrin is taken into corneal epithelial cells by a receptor and prevents corneal damage in dry eye model animals
https://doi.org/10.24517/00062819
https://doi.org/10.24517/000628198b986f1b-d94c-4f9d-b169-4df2a13178af
名前 / ファイル | ライセンス | アクション |
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FR-PR-HIGUCHI-A-36903.pdf (1.5 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-07-05 | |||||
タイトル | ||||||
タイトル | Selenium-binding lactoferrin is taken into corneal epithelial cells by a receptor and prevents corneal damage in dry eye model animals | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00062819 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Higuchi, Akihiro
× Higuchi, Akihiro× Inoue, Hiroyoshi× Kaneko, Yoshio× Oonishi, Erina× Tsubota, Kazuo |
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著者別表示 |
樋口, 明弘
× 樋口, 明弘 |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学先端科学・社会共創推進機構 | |||||
書誌情報 |
Scientific Reports 巻 6, p. 36903, 発行日 2016-11-11 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2045-2322 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1038/srep36903 | |||||
出版者 | ||||||
出版者 | Nature Research | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The ocular surface is strongly affected by oxidative stress, which causes many ocular diseases including dry eye. Previously, we showed that selenium compounds, e.g., selenoprotein P and Se-lactoferrin, were candidates for treatment of dry eye. This paper shows the efficacy of Se-lactoferrin for the treatment of dry eye compared with Diquas as a control drug using two dry eye models and incorporation of lactoferrin into corneal epithelial cells via lactoferrin receptors. We show the efficacy of Se-lactoferrin eye drops in the tobacco smoke exposure rat dry eye model and short-term rabbit dry eye model, although Diquas eye drops were only effective in the short-term rabbit dry eye model. These results indicate that Se-lactoferrin was useful in the oxidative stress-causing dry eye model. Se-lactoferrin was taken into corneal epithelium cells via lactoferrin receptors. We identified LRP1 as the lactoferrin receptor in the corneal epithelium involved in lactoferrin uptake. Se-lactoferrin eye drops did not irritate the ocular surface of rabbits. Se-lactoferrin was an excellent candidate for treatment of dry eye, reducing oxidative stress by a novel mechanism. © 2016 The Author(s). | |||||
権利 | ||||||
権利情報 | Copyright © Nature Research | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.nature.com/srep/index.html | |||||
関連名称 | http://www.nature.com/srep/index.html | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.nature.com/articles/srep36903 | |||||
関連名称 | https://www.nature.com/articles/srep36903 |