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分子生物学的根拠に基づく褥瘡ケア評価基準の開発
https://doi.org/10.24517/00063023
https://doi.org/10.24517/00063023c70b6b9d-2604-4807-8a94-4e1aae13a90e
名前 / ファイル | ライセンス | アクション |
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ME-PR-KONYA-C-kaken 2010-2p.pdf (94.5 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2021-10-29 | |||||
タイトル | ||||||
タイトル | 分子生物学的根拠に基づく褥瘡ケア評価基準の開発 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Development of standard care evaluation of pressure ulcers by the molecular biological approach | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00063023 | |||||
ID登録タイプ | JaLC | |||||
著者 |
紺家, 千津子
× 紺家, 千津子 |
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著者別表示 |
Konya, Chizuko
× Konya, Chizuko |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医学系研究科 | |||||
書誌情報 |
平成18(2006)年度 科学研究費補助金 基盤研究(C) 研究成果報告書概要 en : 2006 Fiscal Year Final Research Report Summary 巻 2005 – 2006, p. 2p., 発行日 2010-02-03 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 本研究の目的は、難治性褥瘡のサイトカインの推移と治癒過程の関係を検討することである。さらに、この関係より難治性の褥瘡に対しケアを変更した時に、このケアが有効であるかを早期に評価できる褥瘡ケア評価基準を作成し、評価するこどである。方法は、難治している褥瘡に通常のケアを導入した後にサイトカインと創の変化を調査し、創の病期別にサイトカインの推移の特徴を導いた。サイトカインは貯留した浸出液からIL-1α・1β、bFGF、IL-4、TGF-β1、VEGF、PDGF-ABをケア変更後3日後と7日後に測定し、創は1週間ごと観察した。なお、対象者からは研究協力の承諾を得た。創の変化別にサイトカインの上昇した割合をみると、ポケットの接着はケア変更7日後のVEGFが6/7、肉芽増殖はケア変更3日後のbFGFが8/8、表皮化はケア変更3日後のbFGFが8/10と高率であった。これ基にケア評価基準を作成し、その陽性反応一致率はbFGFが70.0%、VEGFは66.7%であった。以上より、今回開発した褥瘡のケア評価基準は有効と示唆された。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The purpose of this study was investigated the change in cytokines in refractory pressure ulcers and relationship between its changing and wound healing process. We investigated cytokines in pressure ulcers and wound change patterns in order to clarify cytokine behaviour at each status. After three days and seven days changing care measurements were performed of the levels in retained exudate of the cytokines; interleukin lα and 1β (IL-lα, 1β), basic fibroblast growth factor (bFGF), platelet-derived growth factor-AB (PDGF-AB), interleukin-4 (IL-4), transforming growth factor-β1 (TGF-β1) and vascular endothelial growth factor (VEGF). Wounds were observed weekly. All subjects had consented to participate in the study. Cytokines were increased at each wound change: for undermining adhesion, it was six out of seven (elevation in VEGF at seven three days); for increased granulation, eight out of eight (bFGF at after three days); and for epithelialization also eight out of ten (bFGF at after three days). Standard care evaluation of pressure ulcers was developed from these results. The results of our standard care evaluation were as follow: positive predictive value of bFGF 70.0% and positive predictive value of VEGF 66.7%. Therefore, it was suggested that our standard care evaluation of pressure ulcers was effective. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:17592200, 研究期間(年度):2005 – 2006 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:「分子生物学的根拠に基づく褥瘡ケア評価基準の開発」研究成果報告書 課題番号17592200 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-17592200/175922002006kenkyu_seika_hokoku_gaiyo/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://nrid.nii.ac.jp/ja/search/?kw=20303282 | |||||
関連名称 | https://nrid.nii.ac.jp/ja/search/?kw=20303282 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-17592200/ | |||||
関連名称 | https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-17592200/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-17592200/175922002006kenkyu_seika_hokoku_gaiyo/ | |||||
関連名称 | https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-17592200/175922002006kenkyu_seika_hokoku_gaiyo/ |