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神経膠芽腫浸潤に関与する蛋白分解酵素と細胞外基質のクロストーク及び転写因子の解析
https://doi.org/10.24517/00063416
https://doi.org/10.24517/00063416a635e7b1-70a8-4fc5-bdd5-37edde078582
名前 / ファイル | ライセンス | アクション |
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ME-PR-WATANABE-T-kaken 2007-3p.pdf (131.3 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2021-11-04 | |||||
タイトル | ||||||
タイトル | 神経膠芽腫浸潤に関与する蛋白分解酵素と細胞外基質のクロストーク及び転写因子の解析 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Analysis of transcription factors and of crosstalk between proteinase and extracellular matrix that are related to invasive process of glioblastoma | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00063416 | |||||
ID登録タイプ | JaLC | |||||
著者別表示 |
Watanabe, Takuya
× Watanabe, Takuya |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医学系研究科 | |||||
書誌情報 |
平成17(2005)年度 科学研究費補助金 基盤研究(B) 研究成果報告書概要 en : 2005 Fiscal Year Final Research Report Summary 巻 2003 – 2005, p. 3p., 発行日 2007-12-12 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 本研究は,神経膠芽腫浸潤の際に生じる蛋白分解酵素と脳ECM環境の相互作用を検討し,浸潤抑制治療開発へ新たな知見を加えることを主な目標として行われた. 平成15年度は,脳腫瘍における蛋白分解酵素,matrix metalloproteinaseについてのこれまでの知見を総説として発表した.さらに,神経膠芽腫の浸潤抑制分子として2001年に我々が同定したN-Tes(特許取得)の関連分子であるTestican-2は浸潤の促進に働き,Testican-1,3は抑制に働くことを見出した.この他に,細胞内シグナル伝達機構を担うアダプター蛋白Crk Iのリン酸化が神経膠芽腫の浸潤と関連すること,またアポトーシス誘導因子であるApaf-1の低発現がこの遺伝子存在部位のLOHと関連することなどを報告した. 平成16年度は,大脳基底核部位原発の神経膠芽腫には大脳半球由来のものよりも高頻度にTP53のmutationが起こることを報告した. 平成17年度は,新規のmatrix metaroprotease群ADAMTS familyのうち,ADAMTS-5が神経膠芽腫において高発現しており,さらにこの酵素が脳内のプロテオグリカンを切断することによって脳腫瘍の浸潤過程に関与していることを報告した.その他にも小児の悪性脳腫瘍である髄芽腫についてcyclin D1が予後規定因子となること,また同分子が新しい脳腫瘍概念である異型奇形腫様・類横紋筋腫瘍(AT/RT)においても高発現していることを報告した.さらに,これまでの悪性脳腫瘍における治療法や概念をまとめた「脳腫瘍の外科-Biological behaviorにのっとった新しい治療戦略-」を編纂,出版した. 本研究は,予後不良の悪性脳腫瘍に対して,脳内浸潤の機序や遺伝子発現に関する重要な知見を加えることができた点で,一定の成果を挙げた. |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Our main purpose is to analyze interaction between proteinase and extracellular matrix on glioma invasion. In the year of 2003, we published a review on relationship between matrix metalloproteinase and glioma invasion. We had cloned N-Tes (Patented in 2001), which belongs Testican family and inhibits glioma invasion previously. In addition to this, we found other Testican family (Testican-1 and 3) also suppress invasion of glioma, while Testican-2 contributes invasive activity. Then, we reported that phosphorylation of an adapter protein of Crk I is related to glioma invasion. We also reported that low expression level of Apaf-1 which is an apoptosis inducing protein is related to loss of heterozygosity on chromosome 12 in glioblastoma. In the year of 2004, we reported that almost all the glioblastoma originated from basal ganglia has mutation in TP53 gene. In the year of 2005, we reported that ADAMTS-5,which belongs to ADAMTS family metalloproteinase, is highly expressed in glioblastoma. We also found ADAMTS-5 can degrade brevican which is the most abundant extracellular matrix in brain. In addition to this, we reported that cyclin D1 is related to good prognosis in medulloblastoma and that cyclin D1 is also highly expressed in atypical teratoid/rhabdoid tumor. Then, we edited a book titled, "Brain Tumor Surgery- new strategy based on biological behavior of brain tumors", containing 47 articles of current knowledge on brain tumor therapy. These results are quite fruitful, since we have added some important knowledge on mechanism of invasive process and genetic mutation in glioblastoma, which is the most lethal of brain tumor. |
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内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:15390431, 研究期間(年度):2003 – 2005 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:「神経膠芽腫浸潤に関与する蛋白分解酵素と細胞外基質のクロストーク及び転写因子の解析」研究成果報告書 課題番号15390431 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-15390431/153904312005kenkyu_seika_hokoku_gaiyo/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/ja/search/?kw=90399775 | |||||
関連名称 | https://kaken.nii.ac.jp/ja/search/?kw=90399775 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-15390431/ | |||||
関連名称 | https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-15390431/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-15390431/153904312005kenkyu_seika_hokoku_gaiyo/ | |||||
関連名称 | https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-15390431/153904312005kenkyu_seika_hokoku_gaiyo/ |