WEKO3
インデックスリンク
アイテム
{"_buckets": {"deposit": "dfa3f720-2d15-45d2-b56d-8ca238b128ed"}, "_deposit": {"created_by": 18, "id": "58965", "owners": [18], "pid": {"revision_id": 0, "type": "depid", "value": "58965"}, "status": "published"}, "_oai": {"id": "oai:kanazawa-u.repo.nii.ac.jp:00058965", "sets": ["1875"]}, "author_link": ["91488", "21764", "78846", "22513", "20737", "49560", "84957", "87", "85011", "21761", "115", "103715", "43"], "item_4_biblio_info_8": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2007-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "127", "bibliographicPageStart": "122", "bibliographicVolumeNumber": "48", "bibliographic_titles": [{"bibliographic_title": "Journal of Nuclear Medicine"}]}]}, "item_4_creator_33": {"attribute_name": "著者別表示", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "小川, 数馬"}], "nameIdentifiers": [{"nameIdentifier": "87", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "30347471", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=30347471"}, {"nameIdentifier": "30347471", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=30347471"}, {"nameIdentifier": "30347471", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000030347471"}]}, {"creatorNames": [{"creatorName": "絹谷, 清剛"}], "nameIdentifiers": [{"nameIdentifier": "115", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "20281024", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=20281024"}, {"nameIdentifier": "20281024", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=20281024"}, {"nameIdentifier": "20281024", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000020281024"}]}, {"creatorNames": [{"creatorName": "柴, 和弘"}], "nameIdentifiers": [{"nameIdentifier": "43", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "40143929", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=40143929"}, {"nameIdentifier": "40143929", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=40143929"}, {"nameIdentifier": "40143929", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000040143929"}]}, {"creatorNames": [{"creatorName": "森, 厚文"}], "nameIdentifiers": [{"nameIdentifier": "91488", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90019604", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=90019604"}]}]}, "item_4_description_21": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Previously, based on the concept of bifunctional radiopharmaceuticals, we developed a highly stable 186Re-mercaptoacetylglycylglycylglycine (MAG3) complex-conjugated bisphosphonate, [[[[(4-hydroxy-4,4-diphosphonobutyl) carbamoylmethyl]carbamoylmethyl] carbamoylmethyl]carbamoylmethanethiolate] oxorhenium(V) (186Re-MAG3-HBP), for the treatment of painful bone metastases. This agent showed a superior biodistribution as a bone-seeking agent in normal mice when compared with 186Re-1-hydroxyethylidene-1,1- diphosphonate (186Re-HEDP). In this study, we evaluated the therapeutic effects of 186Re-MAG3-HBP using an animal model of bone metastasis. Methods: The model was prepared by injecting syngeneic MRMT-1 mammary tumor cells into the left tibia of female Sprague-Dawley rats. 186Re-MAG3-HBP (55.5, 111, or 222 MBq/kg) or 186Re-HEDP (55.5 MBq/kg) was then administered intravenously 21 d later. To evaluate the therapeutic effects and side effects, tumor size and peripheral blood cell counts were determined. Palliation of bone pain was evaluated by a von Frey filament test. Results: In the rats treated with 186Re-HEDP, tumor growth was comparable with that in untreated rats. In contrast, when 186Re-MAG3-HBP was administered, tumor growth was significantly inhibited. Allodynia induced by bone metastasis was attenuated by treatment with 186Re-MAG3-HBP or 186Re-HEDP, but 186Re-MAG3- HBP tended to be more effective. Conclusion: These results indicate that 186Re-MAG3-HBP could be useful as a therapeutic agent for the palliation of metastatic bone pain. Copyright © 2006 by the Society of Nuclear Medicine, Inc.", "subitem_description_type": "Abstract"}]}, "item_4_description_5": {"attribute_name": "提供者所属", "attribute_value_mlt": [{"subitem_description": "金沢大学疾患モデル総合研究センター", "subitem_description_type": "Other"}]}, "item_4_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.24517/00065227", "subitem_identifier_reg_type": "JaLC"}]}, "item_4_publisher_17": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Society of Nuclear Medicine"}]}, "item_4_relation_28": {"attribute_name": "関連URI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "http://jnm.snmjournals.org/"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://jnm.snmjournals.org/", "subitem_relation_type_select": "URI"}}, {"subitem_relation_name": [{"subitem_relation_name_text": "https://jnm.snmjournals.org/content/48/1/122"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://jnm.snmjournals.org/content/48/1/122", "subitem_relation_type_select": "URI"}}]}, "item_4_rights_23": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Copyright © Society of Nuclear Medicine"}]}, "item_4_source_id_11": {"attribute_name": "NCID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00703684", "subitem_source_identifier_type": "NCID"}]}, "item_4_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0161-5505", "subitem_source_identifier_type": "ISSN"}, {"subitem_source_identifier": "2159-662X", "subitem_source_identifier_type": "ISSN"}]}, "item_4_version_type_25": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Ogawa, Kazuma"}], "nameIdentifiers": [{"nameIdentifier": "78846", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "30347471", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=30347471"}]}, {"creatorNames": [{"creatorName": "Mukai, Takahiro"}], "nameIdentifiers": [{"nameIdentifier": "49560", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Asano, Daigo"}], "nameIdentifiers": [{"nameIdentifier": "103715", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kawashima, Hidekazu"}], "nameIdentifiers": [{"nameIdentifier": "21761", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kinuya, Seigo"}], "nameIdentifiers": [{"nameIdentifier": "22513", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "20281024", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=20281024"}]}, {"creatorNames": [{"creatorName": "Shiba, Kazuhiro"}], "nameIdentifiers": [{"nameIdentifier": "85011", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "40143929", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=40143929"}]}, {"creatorNames": [{"creatorName": "Hashimoto, Kazuyuki"}], "nameIdentifiers": [{"nameIdentifier": "84957", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "80031798", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=80031798"}]}, {"creatorNames": [{"creatorName": "Mori, Hirofumi"}], "nameIdentifiers": [{"nameIdentifier": "20737", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90019604", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=90019604"}, {"nameIdentifier": "90019604", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000090019604"}]}, {"creatorNames": [{"creatorName": "Saji, Hideo"}], "nameIdentifiers": [{"nameIdentifier": "21764", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2022-02-17"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "ME-PR-SHIBA-K-122.pdf", "filesize": [{"value": "979.4 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 979400.0, "url": {"label": "ME-PR-SHIBA-K-122.pdf", "url": "https://kanazawa-u.repo.nii.ac.jp/record/58965/files/ME-PR-SHIBA-K-122.pdf"}, "version_id": "1422bf01-7325-415c-98dc-1e57e7941bf0"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Bisphosphonate", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Bone metastases", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Internal radiotherapy", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Pain", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Radiopharmaceutical", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Therapeutic effects of a 186re-complex-conjugated bisphosphonate for the palliation of metastatic bone pain in an animal model", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Therapeutic effects of a 186re-complex-conjugated bisphosphonate for the palliation of metastatic bone pain in an animal model"}]}, "item_type_id": "4", "owner": "18", "path": ["1875"], "permalink_uri": "https://doi.org/10.24517/00065227", "pubdate": {"attribute_name": "公開日", "attribute_value": "2022-02-17"}, "publish_date": "2022-02-17", "publish_status": "0", "recid": "58965", "relation": {}, "relation_version_is_last": true, "title": ["Therapeutic effects of a 186re-complex-conjugated bisphosphonate for the palliation of metastatic bone pain in an animal model"], "weko_shared_id": -1}
Therapeutic effects of a 186re-complex-conjugated bisphosphonate for the palliation of metastatic bone pain in an animal model
https://doi.org/10.24517/00065227
https://doi.org/10.24517/00065227a40d3b86-4bdc-4561-a272-fcd6c5a99ed3
名前 / ファイル | ライセンス | アクション |
---|---|---|
ME-PR-SHIBA-K-122.pdf (979.4 kB)
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2022-02-17 | |||||
タイトル | ||||||
タイトル | Therapeutic effects of a 186re-complex-conjugated bisphosphonate for the palliation of metastatic bone pain in an animal model | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00065227 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Ogawa, Kazuma
× Ogawa, Kazuma× Mukai, Takahiro× Asano, Daigo× Kawashima, Hidekazu× Kinuya, Seigo× Shiba, Kazuhiro× Hashimoto, Kazuyuki× Mori, Hirofumi× Saji, Hideo |
|||||
著者別表示 |
小川, 数馬
× 小川, 数馬× 絹谷, 清剛× 柴, 和弘× 森, 厚文 |
|||||
提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学疾患モデル総合研究センター | |||||
書誌情報 |
Journal of Nuclear Medicine 巻 48, 号 1, p. 122-127, 発行日 2007-01 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0161-5505 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2159-662X | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00703684 | |||||
出版者 | ||||||
出版者 | Society of Nuclear Medicine | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Previously, based on the concept of bifunctional radiopharmaceuticals, we developed a highly stable 186Re-mercaptoacetylglycylglycylglycine (MAG3) complex-conjugated bisphosphonate, [[[[(4-hydroxy-4,4-diphosphonobutyl) carbamoylmethyl]carbamoylmethyl] carbamoylmethyl]carbamoylmethanethiolate] oxorhenium(V) (186Re-MAG3-HBP), for the treatment of painful bone metastases. This agent showed a superior biodistribution as a bone-seeking agent in normal mice when compared with 186Re-1-hydroxyethylidene-1,1- diphosphonate (186Re-HEDP). In this study, we evaluated the therapeutic effects of 186Re-MAG3-HBP using an animal model of bone metastasis. Methods: The model was prepared by injecting syngeneic MRMT-1 mammary tumor cells into the left tibia of female Sprague-Dawley rats. 186Re-MAG3-HBP (55.5, 111, or 222 MBq/kg) or 186Re-HEDP (55.5 MBq/kg) was then administered intravenously 21 d later. To evaluate the therapeutic effects and side effects, tumor size and peripheral blood cell counts were determined. Palliation of bone pain was evaluated by a von Frey filament test. Results: In the rats treated with 186Re-HEDP, tumor growth was comparable with that in untreated rats. In contrast, when 186Re-MAG3-HBP was administered, tumor growth was significantly inhibited. Allodynia induced by bone metastasis was attenuated by treatment with 186Re-MAG3-HBP or 186Re-HEDP, but 186Re-MAG3- HBP tended to be more effective. Conclusion: These results indicate that 186Re-MAG3-HBP could be useful as a therapeutic agent for the palliation of metastatic bone pain. Copyright © 2006 by the Society of Nuclear Medicine, Inc. | |||||
権利 | ||||||
権利情報 | Copyright © Society of Nuclear Medicine | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://jnm.snmjournals.org/ | |||||
関連名称 | http://jnm.snmjournals.org/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://jnm.snmjournals.org/content/48/1/122 | |||||
関連名称 | https://jnm.snmjournals.org/content/48/1/122 |