WEKO3
インデックスリンク
アイテム
{"_buckets": {"deposit": "00c62eec-8425-4704-b2f3-099dfeb9672f"}, "_deposit": {"created_by": 18, "id": "61068", "owners": [18], "pid": {"revision_id": 0, "type": "depid", "value": "61068"}, "status": "published"}, "_oai": {"id": "oai:kanazawa-u.repo.nii.ac.jp:00061068", "sets": ["2842"]}, "author_link": ["20433", "22228"], "item_9_biblio_info_8": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1993-03-15", "bibliographicIssueDateType": "Issued"}, "bibliographicPageStart": "2p.", "bibliographicVolumeNumber": "1990 – 1991", "bibliographic_titles": [{"bibliographic_title": "平成3(1991)年度 科学研究費補助金 一般研究(B) 研究成果報告書概要"}, {"bibliographic_title": "1991 Fiscal Year Final Research Report Summary", "bibliographic_titleLang": "en"}]}]}, "item_9_creator_33": {"attribute_name": "著者別表示", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Miyawaki, Toshio"}], "nameIdentifiers": [{"nameIdentifier": "20433", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "10143885", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=10143885"}]}]}, "item_9_description_21": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "平成2、3年の本研究で得られた結果の概要は以下の通りである。\n1.新生児T細胞はCD45RO陰性、CD45RA陽性のnaiveT細胞の形質及び機能的性状をもつが、強いサプレッサ-活性、刺激培養の結果CD45RA陽性からCD45RO陽性に形質転換したmemory様細胞にあっても、ヘルパ-活性はなお不良であるなど、成人naiveT細胞と異なる。\n2.Tγδ細胞の比率は加齢につれ増し、これは主としてCD45RO抗原陽性、抗原応答性をもつBB3陽性サブセットの増加による。が、末梢血の小集団のδTCSー1陽性細胞はCD45RO陰性のnaiveT細胞の性状を示す。\n3.抗CD2抗体によるmemory CD4^+T細胞の増殖反応は単球非存在下でも良好で、ILー2のみならずILー6を産生。他方、naive CD4^+T細胞の抗CD2抗体反応性は微弱であり、ILー6産生欠如が要因である。\n4.伝染性単核症では、CD8^+のみならずCD4^+T細胞がCD45RO抗原を強く発現、CD45RO発現は本症における両T細胞サブセットのEBウイルス感染による活性化状態を示唆する。\n5.抗原応答性というmemoryT細胞の本来の機能に関連して、末梢血memoryT細胞はILー2Rを構成する2つのサブユニット(α、β鎖)を発現。つまり、memory CD4^+T細胞はILー2Rα鎖を、memory CD8^+T細胞はILー2Rβ鎖を発現、ILー2Rサブユニット発現に対応して、memoryT細胞サブセットはILー2添加に強く反応、増殖する。\n6.新生児、小児末梢血CD4^+T細胞の中に、naive形質をもつが、ILー2Rα鎖を発現、memory細胞としてのサイトカイン遺伝子発現能を有する、naiveからmemoryT細胞へ分化途上の小細胞集団が存在する。\n7.全血法により、成熟新生児ではILー6産生能は成人に匹敵するが、未熟児のILー6産生能は未成熟であり、ことに細菌刺激に対するILー6産生が不良であることを明かとした。", "subitem_description_type": "Abstract"}, {"subitem_description": "Naive and memory T cell populations can be discriminated by differential expression of CD45 isoforms. These studies were undertaken to elucidate some functional characteristics of neonatal inherently naive T cells and their maturation steps into memory T cells following increased antigenic exposure after birth. Obtained results are follow as.\n1) Although neonatal T cells share with adult naive T cells in terms to CD45RA expression, they have strong suppressor activity and less helper activity for B cell differentiation even after memory cells-like phenotypic changes by activation.\n2) BB3^+ subsets within T-gamma/delta^+ T cells, but not deltaTCS-1^+ cells, express CD45RO and have the ability to respond to the antigen.\n3) Naive CD4^+ T cells, unlike memory ones, are hyporesponsive to anti-CD2 stimulation, based on their inability to produce IL-6.\n4) Both CD4^+ and CD8^+ T cell populations express CD45RO as well as HLA-DR antigens, indicating strong stimulation with Epstein-Barr infection.\n5) Memory T cells express IL-2 receptor subunits (alpha or chains) and respond well to exogenous IL-2.\n6) A novel population of CD4^+ T cells with naive (CD45RA^+, CD45RO^-) phenotype expressing IL-2R alpha-chain, which express memory-like functions, are identifiable in the blood of newborns and young children. This population represents the cells at the transitional stage from naive to memory T cells.\n7) Full-term newborns can produce IL-6 in response to bacterial pathogens, but IL-6-producing capabilities of preterm babies are still immature.", "subitem_description_type": "Abstract"}]}, "item_9_description_22": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "研究課題/領域番号:02454268, 研究期間(年度):1990 – 1991", "subitem_description_type": "Other"}, {"subitem_description": "出典:研究課題「新生児NaiveT細胞の機能的特異性とMemoryT細胞への分化・成熟」課題番号02454268\n(KAKEN:科学研究費助成事業データベース(国立情報学研究所)) \n(https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-02454268/024542681991kenkyu_seika_hokoku_gaiyo/)を加工して作成", "subitem_description_type": "Other"}]}, "item_9_description_5": {"attribute_name": "提供者所属", "attribute_value_mlt": [{"subitem_description": "金沢大学医学部附属病院", "subitem_description_type": "Other"}]}, "item_9_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.24517/00067312", "subitem_identifier_reg_type": "JaLC"}]}, "item_9_relation_28": {"attribute_name": "関連URI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "https://kaken.nii.ac.jp/search/?qm=10143885"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://kaken.nii.ac.jp/search/?qm=10143885", "subitem_relation_type_select": "URI"}}, {"subitem_relation_name": [{"subitem_relation_name_text": "https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-02454268/"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-02454268/", "subitem_relation_type_select": "URI"}}, {"subitem_relation_name": [{"subitem_relation_name_text": "https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-02454268/024542681991kenkyu_seika_hokoku_gaiyo/"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-02454268/024542681991kenkyu_seika_hokoku_gaiyo/", "subitem_relation_type_select": "URI"}}]}, "item_9_version_type_25": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "宮脇, 利男"}], "nameIdentifiers": [{"nameIdentifier": "22228", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "10143885", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=10143885"}, {"nameIdentifier": "10143885", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000010143885"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2022-10-27"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "HO-PR-MIYAWAKI-T-kaken 1993-2p.pdf", "filesize": [{"value": "93.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 93600.0, "url": {"label": "HO-PR-MIYAWAKI-T-kaken 1993-2p.pdf", "url": "https://kanazawa-u.repo.nii.ac.jp/record/61068/files/HO-PR-MIYAWAKI-T-kaken 1993-2p.pdf"}, "version_id": "1be49a37-2a39-4741-b506-6ba4bcb7700e"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "新生児T細胞", "subitem_subject_scheme": "Other"}, {"subitem_subject": "NaiveT細胞", "subitem_subject_scheme": "Other"}, {"subitem_subject": "MemoryT細胞", "subitem_subject_scheme": "Other"}, {"subitem_subject": "CD45アイソホ-ム", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Tγδ陽性細胞", "subitem_subject_scheme": "Other"}, {"subitem_subject": "インタ-ロイキンー6", "subitem_subject_scheme": "Other"}, {"subitem_subject": "サイトカイン産生能", "subitem_subject_scheme": "Other"}, {"subitem_subject": "T細胞活性化", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Neonatal T cells", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Naive T cells", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Memory T cells", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "CD45 isoforms", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Tgammadelta^+ cells", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Interleukin-6", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Cytokines", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "T cell activation", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "research report", "resourceuri": "http://purl.org/coar/resource_type/c_18ws"}]}, "item_title": "新生児NaiveT細胞の機能的特異性とMemoryT細胞への分化・成熟", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "新生児NaiveT細胞の機能的特異性とMemoryT細胞への分化・成熟"}, {"subitem_title": "Functional Characteristics of Neonatal Naive T cell and Their Maturation into Memory T cell", "subitem_title_language": "en"}]}, "item_type_id": "9", "owner": "18", "path": ["2842"], "permalink_uri": "https://doi.org/10.24517/00067312", "pubdate": {"attribute_name": "公開日", "attribute_value": "2022-10-27"}, "publish_date": "2022-10-27", "publish_status": "0", "recid": "61068", "relation": {}, "relation_version_is_last": true, "title": ["新生児NaiveT細胞の機能的特異性とMemoryT細胞への分化・成熟"], "weko_shared_id": -1}
新生児NaiveT細胞の機能的特異性とMemoryT細胞への分化・成熟
https://doi.org/10.24517/00067312
https://doi.org/10.24517/0006731212e6d26e-0bf3-41b1-a100-9df766b419bf
名前 / ファイル | ライセンス | アクション |
---|---|---|
HO-PR-MIYAWAKI-T-kaken 1993-2p.pdf (93.6 kB)
|
Item type | 報告書 / Research Paper(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2022-10-27 | |||||
タイトル | ||||||
タイトル | 新生児NaiveT細胞の機能的特異性とMemoryT細胞への分化・成熟 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Functional Characteristics of Neonatal Naive T cell and Their Maturation into Memory T cell | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00067312 | |||||
ID登録タイプ | JaLC | |||||
著者 |
宮脇, 利男
× 宮脇, 利男 |
|||||
著者別表示 |
Miyawaki, Toshio
× Miyawaki, Toshio |
|||||
提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医学部附属病院 | |||||
書誌情報 |
平成3(1991)年度 科学研究費補助金 一般研究(B) 研究成果報告書概要 en : 1991 Fiscal Year Final Research Report Summary 巻 1990 – 1991, p. 2p., 発行日 1993-03-15 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 平成2、3年の本研究で得られた結果の概要は以下の通りである。 1.新生児T細胞はCD45RO陰性、CD45RA陽性のnaiveT細胞の形質及び機能的性状をもつが、強いサプレッサ-活性、刺激培養の結果CD45RA陽性からCD45RO陽性に形質転換したmemory様細胞にあっても、ヘルパ-活性はなお不良であるなど、成人naiveT細胞と異なる。 2.Tγδ細胞の比率は加齢につれ増し、これは主としてCD45RO抗原陽性、抗原応答性をもつBB3陽性サブセットの増加による。が、末梢血の小集団のδTCSー1陽性細胞はCD45RO陰性のnaiveT細胞の性状を示す。 3.抗CD2抗体によるmemory CD4^+T細胞の増殖反応は単球非存在下でも良好で、ILー2のみならずILー6を産生。他方、naive CD4^+T細胞の抗CD2抗体反応性は微弱であり、ILー6産生欠如が要因である。 4.伝染性単核症では、CD8^+のみならずCD4^+T細胞がCD45RO抗原を強く発現、CD45RO発現は本症における両T細胞サブセットのEBウイルス感染による活性化状態を示唆する。 5.抗原応答性というmemoryT細胞の本来の機能に関連して、末梢血memoryT細胞はILー2Rを構成する2つのサブユニット(α、β鎖)を発現。つまり、memory CD4^+T細胞はILー2Rα鎖を、memory CD8^+T細胞はILー2Rβ鎖を発現、ILー2Rサブユニット発現に対応して、memoryT細胞サブセットはILー2添加に強く反応、増殖する。 6.新生児、小児末梢血CD4^+T細胞の中に、naive形質をもつが、ILー2Rα鎖を発現、memory細胞としてのサイトカイン遺伝子発現能を有する、naiveからmemoryT細胞へ分化途上の小細胞集団が存在する。 7.全血法により、成熟新生児ではILー6産生能は成人に匹敵するが、未熟児のILー6産生能は未成熟であり、ことに細菌刺激に対するILー6産生が不良であることを明かとした。 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Naive and memory T cell populations can be discriminated by differential expression of CD45 isoforms. These studies were undertaken to elucidate some functional characteristics of neonatal inherently naive T cells and their maturation steps into memory T cells following increased antigenic exposure after birth. Obtained results are follow as. 1) Although neonatal T cells share with adult naive T cells in terms to CD45RA expression, they have strong suppressor activity and less helper activity for B cell differentiation even after memory cells-like phenotypic changes by activation. 2) BB3^+ subsets within T-gamma/delta^+ T cells, but not deltaTCS-1^+ cells, express CD45RO and have the ability to respond to the antigen. 3) Naive CD4^+ T cells, unlike memory ones, are hyporesponsive to anti-CD2 stimulation, based on their inability to produce IL-6. 4) Both CD4^+ and CD8^+ T cell populations express CD45RO as well as HLA-DR antigens, indicating strong stimulation with Epstein-Barr infection. 5) Memory T cells express IL-2 receptor subunits (alpha or chains) and respond well to exogenous IL-2. 6) A novel population of CD4^+ T cells with naive (CD45RA^+, CD45RO^-) phenotype expressing IL-2R alpha-chain, which express memory-like functions, are identifiable in the blood of newborns and young children. This population represents the cells at the transitional stage from naive to memory T cells. 7) Full-term newborns can produce IL-6 in response to bacterial pathogens, but IL-6-producing capabilities of preterm babies are still immature. |
|||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:02454268, 研究期間(年度):1990 – 1991 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:研究課題「新生児NaiveT細胞の機能的特異性とMemoryT細胞への分化・成熟」課題番号02454268 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-02454268/024542681991kenkyu_seika_hokoku_gaiyo/)を加工して作成 |
|||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=10143885 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=10143885 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-02454268/ | |||||
関連名称 | https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-02454268/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-02454268/024542681991kenkyu_seika_hokoku_gaiyo/ | |||||
関連名称 | https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-02454268/024542681991kenkyu_seika_hokoku_gaiyo/ |