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Since the STR reflects post-photoreceptoral processing in the retina at intensities near absolute threshold, the STR would be a useful index to evaluate the rod pathway in the proximal retina. A conventional ERG setup, however, involves difficulties in STR recording. Therefore we constructed a new recording system for the purpose. The characteristics of the apparatus are as follows : 1)A diffusing sphere provides full-field stimuli ranging from a very dim light near absolute threshold to a very bright light. 2)A remote-control system for changing filters is used to avoid breakdown of the dark-adapted status. 3)A software artifact rejection routine is used to exclude response influenced by eye movements and blinks. Using the apparatus we have examined the human STR and generally confirmed the previous findings.\nFundus albipunctatus is known as having a prolonged dark adaptation in both rod and cone systems due to a disorder of visual pigment regeneration. We previously reported that the amplitude of the b-wave with a dim light and the early receptor potential with a bright flash recovered slowly along the course of progressive dark adaptation and ended up non-nal after 34 hours of dark adaptation in a case of the disease. The threshold of the b-wave is, however, about 3.5 - 4.0 log higher than the psychophysical threshold. Thus the relationship between psychophysical sensitivity and electrical response below the b-wave threshold has been missing. Since the threshold of the STR is lower than the b-wave threshold, the STR is an appropriate electrical index for evaluating. scotopic activity. In a 7 year-old girl with fundus albipunctatus the characteristics of the STR from the fully dark adapted eye were normal, including the maximum amplitude, waveform, range of stimulus intensity and relationship to rod PII, suggesting a physiological deficit rather than a dystrophic involvement in the disease.\nAbetalipoproteinemia (Bassen - Komzweig syndrome) is a rare autosomal ressesive disease characterized clinically by acanthocytosis, cerebeller ataxia, fat malabsorption and atypical retinitis pigmentosa. In a patient of the disease, findings of ocular fundus, fluorescein angiography, color vision, visual field and dark adaptation were all compatible to those of typical retinitis pigmentosa sine pigment. ERG and EOG findings recorded from the patient suggested that the main affected site of the disease is different from primary retinitis pigmentosa.\nThe scotopic threshold response (STR) was reported in the cat, sheep monkey and human. The STR has not yet been confirmed in the frog and rabbit. We recorded the ERG intensity series in the frog and rabbit, using dim (-7.7 log) to bright (O log : 280cd/m^2) full field stimli. The threshold of the b-wave in the frog was about -5.7 log intensity. Below the b-wave threshold (at the intensities of -6.3 and -6.7 log), a tiny negative wave (3 - 6[muV) with a long latency (450 msec) seemed to be barely observed indicating that the frog STR is a very tiny tranasient response if present. The threshold of the b-wave in the rabbit was about -5.3 log intensity. Below the b-wave threshold no negative wave was observed in the rabbit. On the hypothesis that membrane potential change of Muller cell in response to extracellular K\n^+ concentration serves to generate the STR, the differences of the distribution of K^+ conductance of Muller cells among the species may account for the low STR amplitude in the frog and rabbit in comparison with the high STR amplitude in the cat and monkey.", "subitem_description_type": "Abstract"}]}, "item_9_description_22": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "研究課題/領域番号:02807162, 研究期間(年度):1990 – 1991", "subitem_description_type": "Other"}, {"subitem_description": "出典:研究課題「網膜電図の新電位(暗所閾値電位,STR)の発生機構の基礎的および臨床的研究」課題番号02807162\n(KAKEN:科学研究費助成事業データベース(国立情報学研究所)) \n(https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-02807162/028071621991kenkyu_seika_hokoku_gaiyo/)を加工して作成", "subitem_description_type": "Other"}]}, "item_9_description_5": {"attribute_name": "提供者所属", "attribute_value_mlt": [{"subitem_description": "金沢大学医学部附属病院", "subitem_description_type": 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網膜電図の新電位(暗所閾値電位,STR)の発生機構の基礎的および臨床的研究
https://doi.org/10.24517/00067323
https://doi.org/10.24517/000673232a2c7c03-5b4c-44a0-b2a3-3f26fa112a50
名前 / ファイル | ライセンス | アクション |
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HO-PR-WAKABAYSHI-K-kaken 1993-2p.pdf (112.0 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2022-10-27 | |||||
タイトル | ||||||
タイトル | 網膜電図の新電位(暗所閾値電位,STR)の発生機構の基礎的および臨床的研究 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Basic and Clinical Aspects of the Scotopic Threshold Response, (STR) | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00067323 | |||||
ID登録タイプ | JaLC | |||||
著者 |
若林, 謙二
× 若林, 謙二 |
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著者別表示 |
Wakabayashi, Kenji
× Wakabayashi, Kenji |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医学部附属病院 | |||||
書誌情報 |
平成3(1991)年度 科学研究費補助金 一般研究(C) 研究成果報告書概要 en : 1991 Fiscal Year Final Research Report Summary 巻 1990 – 1991, p. 2p., 発行日 1993-03-15 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 前年度に開発した暗所閾値電位(scotopic threshold response,STR)記録システムを用いて 1)ウサギおよびカエルにおいてin vivo STRの記録を試み、STRの種差について検討することによりSTRにおけるMuller細胞の関与の可能性を検討した。その結果カエルおよびウサギではSTRに相当する陰性波は観察されなかった。これまでにSTRを持つことが明らかにされているヒトやネコおよびサルと今回検討を行ったウサギおよびカエルとではMuller細胞のK^+透過性分布が異なるとされており、Muller細胞のK^+透過性分布の違いとSTRの有無とが符合することはSTRの発生にMuller細胞が関与していることの傍証となると考えられた。 2)ヒトにおいては眼底白点症および無βリポ蛋白血症においてSTRの所見を検討した。眼底白点症は視物質の再生遅延によって暗順応が延長する疾患であるが、今回の検討では本症の3例において充分な暗順応後のSTRは他の網膜電図(electroretinogram,ERG)成分と同様に正常であり、電気生理学的にも充分な暗順応後の網膜機能が正常であることを示した。無βリポ蛋白血症は血清βリポ蛋白の消失を本態とする常染色体劣性遺伝の疾患であり、腸管における脂肪の吸収不全から各種脂容性ビタミンの欠乏症状を呈し眼科的には非定型的網膜色素変性症を合併することで知られている。今回の検討では本症の1例でSTRは観察されず、ERGa波およびb波も高度に減弱していたが、同症例で記録した眼球電位図では異常の程度が原発性網膜色素変性症に比べて軽度であったこととあわせて考えると本症における網膜色素変性症は原発性網膜色素変性症とはその主たる障害の部位が異なる可能性が示唆された。 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The scotopic threshold response (STR) is a newly investigated component of the electroretinogram. Since the STR reflects post-photoreceptoral processing in the retina at intensities near absolute threshold, the STR would be a useful index to evaluate the rod pathway in the proximal retina. A conventional ERG setup, however, involves difficulties in STR recording. Therefore we constructed a new recording system for the purpose. The characteristics of the apparatus are as follows : 1)A diffusing sphere provides full-field stimuli ranging from a very dim light near absolute threshold to a very bright light. 2)A remote-control system for changing filters is used to avoid breakdown of the dark-adapted status. 3)A software artifact rejection routine is used to exclude response influenced by eye movements and blinks. Using the apparatus we have examined the human STR and generally confirmed the previous findings. Fundus albipunctatus is known as having a prolonged dark adaptation in both rod and cone systems due to a disorder of visual pigment regeneration. We previously reported that the amplitude of the b-wave with a dim light and the early receptor potential with a bright flash recovered slowly along the course of progressive dark adaptation and ended up non-nal after 34 hours of dark adaptation in a case of the disease. The threshold of the b-wave is, however, about 3.5 - 4.0 log higher than the psychophysical threshold. Thus the relationship between psychophysical sensitivity and electrical response below the b-wave threshold has been missing. Since the threshold of the STR is lower than the b-wave threshold, the STR is an appropriate electrical index for evaluating. scotopic activity. In a 7 year-old girl with fundus albipunctatus the characteristics of the STR from the fully dark adapted eye were normal, including the maximum amplitude, waveform, range of stimulus intensity and relationship to rod PII, suggesting a physiological deficit rather than a dystrophic involvement in the disease. Abetalipoproteinemia (Bassen - Komzweig syndrome) is a rare autosomal ressesive disease characterized clinically by acanthocytosis, cerebeller ataxia, fat malabsorption and atypical retinitis pigmentosa. In a patient of the disease, findings of ocular fundus, fluorescein angiography, color vision, visual field and dark adaptation were all compatible to those of typical retinitis pigmentosa sine pigment. ERG and EOG findings recorded from the patient suggested that the main affected site of the disease is different from primary retinitis pigmentosa. The scotopic threshold response (STR) was reported in the cat, sheep monkey and human. The STR has not yet been confirmed in the frog and rabbit. We recorded the ERG intensity series in the frog and rabbit, using dim (-7.7 log) to bright (O log : 280cd/m^2) full field stimli. The threshold of the b-wave in the frog was about -5.7 log intensity. Below the b-wave threshold (at the intensities of -6.3 and -6.7 log), a tiny negative wave (3 - 6[muV) with a long latency (450 msec) seemed to be barely observed indicating that the frog STR is a very tiny tranasient response if present. The threshold of the b-wave in the rabbit was about -5.3 log intensity. Below the b-wave threshold no negative wave was observed in the rabbit. On the hypothesis that membrane potential change of Muller cell in response to extracellular K ^+ concentration serves to generate the STR, the differences of the distribution of K^+ conductance of Muller cells among the species may account for the low STR amplitude in the frog and rabbit in comparison with the high STR amplitude in the cat and monkey. |
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内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:02807162, 研究期間(年度):1990 – 1991 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:研究課題「網膜電図の新電位(暗所閾値電位,STR)の発生機構の基礎的および臨床的研究」課題番号02807162 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-02807162/028071621991kenkyu_seika_hokoku_gaiyo/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=50126629 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=50126629 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-02807162/ | |||||
関連名称 | https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-02807162/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-02807162/028071621991kenkyu_seika_hokoku_gaiyo/ | |||||
関連名称 | https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-02807162/028071621991kenkyu_seika_hokoku_gaiyo/ |