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運動刺激に対する内分泌代謝系反応の解析と生理的負荷試験への応用
https://doi.org/10.24517/00067324
https://doi.org/10.24517/00067324ed16d7b5-1192-4e32-b535-7d17b4945793
名前 / ファイル | ライセンス | アクション |
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ME-PR-HASHIMOTO-T-kaken 1993-3p.pdf (114.5 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2022-10-27 | |||||
タイトル | ||||||
タイトル | 運動刺激に対する内分泌代謝系反応の解析と生理的負荷試験への応用 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Analysis of endocrine-metabolic systems during exercise and clinical applications of exercise for laboratory test. | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00067324 | |||||
ID登録タイプ | JaLC | |||||
著者 |
橋本, 琢磨
× 橋本, 琢磨 |
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著者別表示 |
Hashimoto, Takuma
× Hashimoto, Takuma |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医学部 | |||||
書誌情報 |
平成3(1991)年度 科学研究費補助金 一般研究(C) 研究成果報告書概要 en : 1991 Fiscal Year Final Research Report Summary 巻 1990 – 1991, p. 3p., 発行日 1993-03-15 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 1.糖質代謝ホルモンとしてグルカゴン、インスリン、ソマトスタチンの測定を行った結果、インスリンの減少とグルカゴンの増加がみられた。ソマトスタチンは不定であった。2.甲状腺ー副甲状腺系では、FT_3,FT_4,PTHの増加とカルチトニンの低下がみられた。オステオカルシンは増加した。3.水分代謝に関しては、ADH,HANPの有意の上昇がみられた。4.消化管ホルモンであるモチリン,VIP,CCK,セクレチン,サブスタンスPは不変であった。5.尿中GHは有意の増加を示した。6.60%VO_2max15分間の運動の際のT_4の代謝を調べたところ、rT_4とT_3への転換は同程度であった。これは筋肉内で5脱ヨ-ド酵素と5脱ヨ-ド酵素が同程度に活性化されたことを意味する。7.従来、生理的な量の甲状腺ホルモンは蛋白の合成をたかめ、蛋白同化作用を発揮するが非生理的に過剰な甲状腺ホルモンは異化が亢進して、血中アルブミン直は低くなり、窒素平衡は負に傾くようになると言われている。今回の研究とFT_3と総蛋白、アルブミン、トランスフェリン、シアル酸、尿素窒素において正相関がみられた。これはFT_3が蛋白代謝に同化作用的に関与していることを示す。8.FT_3斟と総コレステロ-ル、フリ-コレステロ-ル、HDL、燐脂質、ApoA_1、ApoB、ApoE、LDL、と正相関がみられた。これは脂質代謝におけるFT_3の重要性を示す。9.FT_3はALP、GPT、LAP、ChE、クレアチンキナ-ゼと正相関を示した。10.この他血中生化学物質との相関は多くのホルモンと認められたが、その意義については目下検討中である。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Exercise can affect numerous biochemical variables. We consider it is very important to clarify the effect of exercise(short-term exercise e. g. a bicycle ergometer at 60% VO_2max for 15 min.) in order to establish a reliable physiological loading test in the clinical laboratory fields. We therefore decided to investigate I)the effect exercise on endocrinological organs 2)the effect of exercise on the blood chemical variables(laboratory tests)3)the simultaneous effect of the hormonal changes on the blood chemistry and the relationship between them. One hundred and thirty male students, aged 23-26 yr, were subjected to exercise on a bicycle ergometer at 60% VO_2max for 15 min. Blood was collected just before and immediately after exercise. Plasma catecholamines(adrenaline(AD), noradrenaline(NAD)and doparmine)were measured using the HPLC method. Other serum hormones were measured by RIA or EIA and 70 serum chemicals were determined by routine methods. After exercise, mean AD, NAD, ACTH, PRL, GH, TSH, Aldosterone, renin, cortisol, gulcagon, FT_3, FT_4, PTH, osteocalcin, ADH, HANP, somatomedine C, Vitamine D_3, erythropoietin, and thyroxine binding globulin(TBG)showed a significant increase. On the other hand, serum calcitonin, insulin and c-peptide decreased signifidantly. Dopamine, LH, FSH, estradiol, somatostatin, motilin, VIP, CCK, secretin, substance P and neurotensin showed no change. Thirty two out of 70 chemical substances(enzymes, lipids and electrolytes etc.)were significantly increased but 4 decreased. The greatest increase was in NEFA(non-estrified free fatty acid)and the greatest decrease was in chylomicrons. The relationship of % changes of all determinants was calculated using a computer. Many correlations between hormones and biochemical components were found. For example, we revealed 24 correlations between thyroid and parathyroid hormones and biochemical components. We firstly demonstrated the importance of FT3 not only in protein metabolism but also in lipid metabolism. Further studies on exercise-induced hormonal change and the interrelationship between hormones and biochemical variables should be carried out. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:02671067, 研究期間(年度):1990 – 1991 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:研究課題「運動刺激に対する内分泌代謝系反応の解析と生理的負荷試験への応用」課題番号02671067 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-02671067/026710671991kenkyu_seika_hokoku_gaiyo/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=10124710 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=10124710 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-02671067/ | |||||
関連名称 | https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-02671067/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-02671067/026710671991kenkyu_seika_hokoku_gaiyo/ | |||||
関連名称 | https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-02671067/026710671991kenkyu_seika_hokoku_gaiyo/ |