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NK細胞の分化段階と造血幹細胞分化増殖調節機構への関与, NK細胞性白血病症例の検討
https://doi.org/10.24517/00067907
https://doi.org/10.24517/0006790711613643-af6c-4922-8683-57fa3e2e49a9
名前 / ファイル | ライセンス | アクション |
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HO-PR-KOIZUMI-S-kaken 1989-2p.pdf (88.7 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2022-11-11 | |||||
タイトル | ||||||
タイトル | NK細胞の分化段階と造血幹細胞分化増殖調節機構への関与, NK細胞性白血病症例の検討 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Malignant clonal expansion of an NK cell subpopulation andits suppressive effect on the growth of hemopoietic stem cells. | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00067907 | |||||
ID登録タイプ | JaLC | |||||
著者 |
小泉, 晶一
× 小泉, 晶一 |
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著者別表示 |
Koizumi, Shoichi
× Koizumi, Shoichi |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医学部附属病院 | |||||
書誌情報 |
昭和62(1987)年度 科学研究費補助金 一般研究(C) 研究成果報告書概要 en : 1987 Fiscal Year Final Research Report Summary 巻 1986 – 1987, p. 2p., 発行日 1989-03-29 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | NK細胞は造血幹細胞の分化, 増殖機構の調節に重要な役割を担っていることが知られている. 我々は14才女子のNK細胞白血病症例を経験した. このNK細胞はLGL細胞の形態を有し, 表面形質は, Leu7陰性,Leu11陽性であった. 又T11陽性だが, T3,T8,OKM1陰性で, Tγリンパ球に属すると考えられた. NK活性は低値であったが, γIL2で著明に増強された. しかし, IFNγでは増強されなかったことより, このNK亜型は, 未熟NK, 又はNK前駆細胞に相当すると思われた. ADCC及びLAK活性もγIL2刺激後に認められた. 本症例では, 経過中常に顆粒球減少症が認められたため, invitroコロニー法で, NK細胞のヒト骨髄CFU-Cに対する影響を検討した. γIL2刺激後のNK細胞を添加したところ著明なCFU-Cの減少が認められた. NK細胞の培養上清にも同様な強い抑制効果が認められた. 上清を抗IFNγ抗体で前処理することにより抑制効果が解除された. 抗IFNの抗体では2つのような効果は認められなかったことより, 上清中のIFNγがCFU-C抑制に重要な役割を演じているものと思われた. 患者血液中でもIFNγの高値が測定された. 以上の結果より, Leu7^-,Leu11^+NK細胞は, IL2の刺激により, IFNγの産生を介して, 骨髄顆粒球系前駆細胞の増殖を抑制していると考えられた. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Natural killer (NK) cells, morphologically indistinguishable from large granular lymphocytes (LGLs), are thought to have an important role in the regulation of hematopoiesis. A clonal leukemic population of NK cells was isolated from a 14-year-old girl. They had a Leu-11^+, Leu-7^- phenotype. Since the NK activity was low but was remarkably augmented by stimulation with recombinant human interleukin 2 (rIL-2), but not interferon- (IFN-<gamma>), this NK subset seems to belong to a premature stage in the maturation of NK cells. Because of severe neutropenia throughout the clinical course, we investigated the effects of this NK subpopulation on the in vitro growth of granulocyte-macrophage colony forming cells (GM-CDC). When this NK subset in the presence of rIL-2 was added to the GM-CFC assay system employing normal bone marrow cells, a remarkable suppression of GM-CFC was demonstrated. Culture supernatants from the rIL-2-stimulated NK cells, which had a high level of IFN-<gamma>, also exhibited a significant suppressive activity. Treatment of the supernatants with a specific antibody against IFN-<gamma> abrogated the inhibitory effect on GM-CFC. These data indicate that this unique subset of premature NK cells in the presence of rIL-2 produceIFN-<gamma> which seems to be involved in the suppression of myelopoietic progenitor cells. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:61570447, 研究期間(年度):1986 – 1987 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:研究課題「NK細胞の分化段階と造血幹細胞分化増殖調節機構への関与, NK細胞性白血病症例の検討」課題番号61570447 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-61570447/615704471987kenkyu_seika_hokoku_gaiyo/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=50019973 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=50019973 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-61570447/ | |||||
関連名称 | https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-61570447/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-61570447/615704471987kenkyu_seika_hokoku_gaiyo/ | |||||
関連名称 | https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-61570447/615704471987kenkyu_seika_hokoku_gaiyo/ |