日本医療薬学会 = Japanese Society of Pharmaceutical Health Care and Sciences
抄録
The purpose of this study was to investigate whether the trough plasma concentration of voriconazole (VRCZ) in the steady-state (Cmin) influences efficacy and safety in adult and pediatric patients. Treatment was successful in 75% of pediatric patients and 56% of adult patients,and there was no association between Cmin and efficacy.However,liver dysfunction occurred more frequently in the case that Cmin was over 4μg/mL in both adult and pediatric patients.Also,pediatric patients,especially those younger than 2 years,required a higher dose of VRCZ than adults to achieve a similar Cmin. We concluded that the use of VRCZ at a constant dose over a long period may lead to an increase in Cmin.Therefore,careful,continuous monitoring of the Cmin of VRCZ is necessary for pediatric patients,particularly recipients of hematopoietic stem cell transplantation.
小児と成人におけるボリコナゾールの血中濃度解析の比較
PH-PR-ISHIZAKI-J-213.pdf
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