筋衛星細胞の活性化とMyoDファミリーの発現を指標とした運動負荷量の設定が臨床的に効率的と考えた。正常筋で筋衛星細胞の活性化閾値とMyoDファミリー発現を分析後、萎縮筋と正常筋の相違を検証した。理学療法学の観点から、萎縮筋における介入至適条件を、荷重と歩行の比較分析から考察した。過大な負荷による筋損傷を避けた、安全な運動負荷量設定には、活性化閾値の利用と病理学的観察の併用が有用と考えられた。
We thought that the setting of proper exercise load used activation in satellite cell and expression of MyoD family in skeletal muscle as index was clinically effective. After research on the activation threshold of satellite cells and expression of MyoD family in normal muscle, we analyzed the difference between atrophy and normal muscle. From the viewpoint of physical therapy, we considered optimal intervention condition in atrophy muscle from comparison analysis in weight-bearing and gait. It was thought that combination of the use of the activation threshold and pathological observation was important to the setting of proper exercise load that avoided muscle damage by excessive load.
骨格筋衛星細胞活性化とMyoDファミリー発現を指標とした至適運動負荷量の設定
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