2026-03-12T19:59:44Z https://kanazawa-u.repo.nii.ac.jp/oai

oai:kanazawa-u.repo.nii.ac.jp:00013050 2024-06-20T07:16:01Z 1132:1133:1134

Difference in the risk factors for coronary, renal and other peripheral arteriosclerosis in heterozygous familial hypercholesterolemia 30293343 Yagi, Kunimasa Hifumi, Senshu 50313648 Nohara, Atsushi Higashikata, Toshinori 80293348 Inazu, Akihiro Mizuno, Kiyoo Namura, Masanobu Ueda, Kosei 60302577 Kobayashi, Junji Shimizu, Masami 00019960 Mabuchi, Hiroshi 循環器学会の許諾を得て登録 Background: The aim of the present study was to clarify the risk factors of several types of arteriosclerosis lesions in Japanese individuals with heterozygous familial hypercholesterolemia (FH): renal arteriosclerosis (RAS), abdominal aortic sclerosis (AOS), iliac arteriosclerosis (IAS) and coronary artery disease (CAD). Methods and Results: Coronary angiography (CAG) and abdominal aortic angiography (AAA) were performed in 117 consecutive heterozygous FH subjects (79 men, 38 women; age 22-76). RAS (stenotic lesion or aneurysm) was observed in 39 cases (33%), predominantly in the proximal portion (74%) and both sides equally (right/left=27/23). Most cases of RAS (64%) presented with <25% stenosis. The differences in the contributing risk factors for the progression and development of RAS, AOS, IAS and CAD in FH were then analyzed. Multiple logistic regression analyses showed independent risk factors for formation of atherosclerosis in each artery were: age alone for RAS; age and plasma low-density lipoprotein cholesterol (LDL-C) for AOS; age, LDL-C and high-density lipoprotein cholesterol (HDL-C) for IAS; and HDL-C and diabetes mellitus for CAD. Conclusion: In Japanese subjects with heterozygous FH, there are distinct risk factors for the development and progression of atherosclerosis in the renal, iliac, abdominal aorta, and coronary arteries. 金沢大学大学院医学系研究科 日本循環器学会 2004-07-01 2017-10-03 eng journal article VoR http://hdl.handle.net/2297/7204 https://kanazawa-u.repo.nii.ac.jp/records/13050 https://doi.org/10.1253/circj.68.623 AA11591968 1346-9843 Circulation Journal 68 7 623 627 https://kanazawa-u.repo.nii.ac.jp/record/13050/files/ME-PR-MABUCHI-H-P623.pdf application/pdf 67.5 kB 2017-10-03