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Association of the C825T polymorphism of the G-protein β3 subunit gene with hypertension, obesity, hyperlipidemia, insulin resistance, diabetes, diabetic complications, and diabetic therapies among Japanese Hayakawa, Tetsuo 00324111 Takamura, Toshinari Abe, Toshio 60185923 Kaneko, Shuichi A C825T polymorphism of the gene encoding the G-protein β3 subunit (GNB3) is associated with increased intracellular signal transduction. We know that this C825T polymorphism may influence hypertension and obesity. In whites, the C825T polymorphism has been reported to induce hypertension, obesity, and diabetic nephropathy. Thus, we investigated how genetic variation in the GNB3 gene is associated with hypertension, obesity, insulin resistance, diabetes, diabetic complications, and diabetic therapies in 427 Japanese subjects with type 2 diabetes mellitus and in 368 Japanese subjects who underwent general health examinations. The frequency of the GNB3 gene polymorphism was 0.48 and 0.47 in subjects with diabetes and in those who had general health examinations, respectively. The amount of hyperlipidemia of the CT allele was significantly lower than the amount in the CC allele in the Japanese subjects with diabetes. Our results suggest that the C825T polymorphism influences lipid metabolism and is not associated with hypertension, obesity, insulin resistance, diabetes, diabetic complications, or diabetic therapies. © 2007. 金沢大学大学院医学系研究科環境社会医学 Elsevier BV 2007-01-01 2017-10-03 eng journal article AM http://hdl.handle.net/2297/3469 https://kanazawa-u.repo.nii.ac.jp/records/13200 https://doi.org/10.1016/j.metabol.2006.08.020 http://www.elsevier.com/locate/issn/00260495 AA0073583X 0026-0495 Metabolism: Clinical and Experimental 56 1 44 48 https://kanazawa-u.repo.nii.ac.jp/record/13200/files/ME-PR-TAKAMURA-T-0260495.pdf application/pdf 321.1 kB 2017-10-03