2026-03-09T00:48:21Z https://kanazawa-u.repo.nii.ac.jp/oai

oai:kanazawa-u.repo.nii.ac.jp:00026659 2024-06-25T04:48:32Z 1761:1762:1763

Chemokines in renal diseases 40334784 Wada, Takashi 和田, 隆志 50191531 Yokoyama, Hitoshi 50222427 Matsushima, Koji Kobayashi, Kenichi The interaction of activated leukocytes and renal resident cells is thought to play a crucial role in the pathogenesis of renal diseases. Recent investigations of the pathophysiological roles of chemokines and their cognate receptors have shed light on the detailed molecular mechanisms of leukocyte trafficking and activation in the diseased kidneys. Chemokine/chemokine receptor systems may be essentially involved in the pathogenesis of phase-specific renal disorders and the measurement of urinary levels of chemokines may be clinically useful for monitoring the different disease phases and activities. In addition, chemokine receptors expressed in renal resident cells may be involved in proliferation, fibrogenesis, as well as chemotaxis. The selective intervention of chemokine/chemokine receptor systems (anti-chemokine therapy) may have the potential as the particular therapeutic strategies for renal diseases in future Elsevier 2001-04-01 2017-10-05 eng journal article AM http://hdl.handle.net/2297/1765 https://kanazawa-u.repo.nii.ac.jp/records/26659 https://doi.org/10.1016/s1567-5769(01)00004-2 http://www.elsevier.com/locate/issn/15675769 1567-5769 International Immunopharmacology 1 4 637 645 https://kanazawa-u.repo.nii.ac.jp/record/26659/files/HO-PR-WADA-T.pdf application/pdf 129.6 kB 2017-10-05