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        <identifier>oai:kanazawa-u.repo.nii.ac.jp:00052868</identifier>
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          <dc:title>尿路性器腫瘍に対するヒトパピローマウイルス感染の関連性についての検討</dc:title>
          <dc:title xml:lang="en">Etiological role of human papillomavirus infection in the development of urogenital tumor</dc:title>
          <jpcoar:creator>
            <jpcoar:creatorName>重原, 一慶</jpcoar:creatorName>
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          <datacite:description descriptionType="Abstract">尿路HPV感染を調査する上で最も簡便かつ非浸襲的な方法は、尿検体を使用することと考え、子宮頸癌検診で汎用されている液状細胞診を応用することにより、HPV-PCR検査と細胞診が同時に可能であることを報告した。また、女性膀胱腫瘍84例を対象とした検討では、HPV検出率は6.0%(5例)であった。その5例について、分子細胞学的手法を用いて、感染したHPVが腫瘍の発生に関与していることを示唆し得るデータを得た。同様に日本人陰茎癌の47%がHPV感染に関連したものであったことを突き止めた。</datacite:description>
          <datacite:description descriptionType="Abstract">Firstly, as urine samples are suitable for large-scale studies of not only HPV but also other microorganisms that cause urethritis because of the ease and noninvasive nature of sampling, we have attempted to improve the analysis methods using urinary samples. We found that this method is applicable for detection of HPV in urine. In addition, eighty-four female patients with primary bladder tumor were studied. HPV-DNA was detected in 5 (6.0%) of 84 eligible patients, and we demonstrated that HPV infection is likely to play an important role in the development of female bladder tumorbased on various histopathological and molecular methods. Furthermore, we found that 47% of penile cancer was likely to be associated with penile HPV infection.</datacite:description>
          <datacite:description descriptionType="Other">研究課題/領域番号:23791748, 研究期間(年度):2011 – 2012</datacite:description>
          <datacite:description descriptionType="Other">出典：研究課題「尿路性器腫瘍に対するヒトパピローマウイルス感染の関連性についての検討」課題番号23791748
（KAKEN：科学研究費助成事業データベース（国立情報学研究所））
（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-23791748/23791748seika/）を加工して作成</datacite:description>
          <datacite:description descriptionType="Other">金沢大学医薬保健研究域医学系</datacite:description>
          <datacite:date dateType="Issued">2013-05-20</datacite:date>
          <dc:language>jpn</dc:language>
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          <jpcoar:identifier identifierType="DOI">https://doi.org/10.24517/00059161</jpcoar:identifier>
          <jpcoar:identifier identifierType="HDL">http://hdl.handle.net/2297/00059161</jpcoar:identifier>
          <jpcoar:identifier identifierType="URI">https://kanazawa-u.repo.nii.ac.jp/records/52868</jpcoar:identifier>
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            <jpcoar:relatedIdentifier identifierType="URI">https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-23791748/</jpcoar:relatedIdentifier>
            <jpcoar:relatedTitle>https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-23791748/</jpcoar:relatedTitle>
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            <jpcoar:relatedIdentifier identifierType="URI">https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-23791748/23791748seika/</jpcoar:relatedIdentifier>
            <jpcoar:relatedTitle>https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-23791748/23791748seika/</jpcoar:relatedTitle>
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          <jpcoar:sourceTitle>平成24(2012)年度 科学研究費補助金 若手研究(B) 研究成果報告書</jpcoar:sourceTitle>
          <jpcoar:sourceTitle xml:lang="en">2012 Fiscal Year Final Research Report</jpcoar:sourceTitle>
          <jpcoar:volume>2011 – 2012</jpcoar:volume>
          <jpcoar:pageStart>4p.</jpcoar:pageStart>
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            <datacite:date dateType="Available">2020-11-02</datacite:date>
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