2026-03-10T03:47:05Z https://kanazawa-u.repo.nii.ac.jp/oai

oai:kanazawa-u.repo.nii.ac.jp:00058614 2024-06-20T07:07:14Z 1132:1133:1134

Predictors of exercise-induced oxygen desaturation in systemic sclerosis patients with interstitial lung disease 染矢, 富士子 麦井, 直樹 60187903 Someya, Fujiko Mugii, Naoki Hasegawa, Minoru Yahata, Tetsutarou Nakagawa, Takao Copyright © 2014 Daedalus Enterprises, published by the American Association for Inhalation Therapy Background: The diffusion capacity of the lung for carbon monoxide (DLCO) is a good marker of disease severity in patients with idiopathic interstitial pneumonia, and is associated with oxygen saturation; however, little is known about DLCO in systemic sclerosis patients with interstitial lung disease. We studied potential predictors of exercise-induced oxygen desaturation in patients with systemic sclerosis. Methods: Data were collected prospectively from 80 of 110 consecutive systemic sclerosis patients with normal oxygen saturation (> 95%) at rest, who could perform the 6-min walk test without physical discomfort, including leg pain. Pulmonary function tests and echocardiography were collected from all subjects. Results: Thirty subjects showed a ≥ 4% decline in oxygen saturation during the 6-min walk test (desaturation group). The other subjects were assigned to the normoxic group. The percent-of-predicted values for FVC, FEV1, total lung capacity, DLCO, and DLCO/alveolar volume were lower, and FEV1/FVC was higher, in the desaturation group. Logistic regression analysis showed the percent-of-predicted DLCO as a highly accurate predictor of exercise-induced oxygen desaturation: the area under the receiver operating characteristic curve was 0.92 (cutoff point 56.3%, sensitivity 0.83, specificity 0.86). Five subjects over the cutoff point of the percent-of-predicted DLCO in the desaturation group could not be distinguished from the normoxic subjects with the lung-volume measurements or right-ventricular systolic pressure. Conclusions: The factor underlying exercise-induced oxygen desaturation appeared to be reduced percent-of-predicted DLCO, which was useful as a predictor in over 80% of the subjects. © 2014 Daedalus Enterprises. 金沢大学医薬保健研究域保健学系 American Association for Inhalation Therapy 2014-01 2022-02-03 eng journal article VoR https://doi.org/10.24517/00064882 http://hdl.handle.net/2297/00064882 https://kanazawa-u.repo.nii.ac.jp/records/58614 10.24517/00064882 10.4187/respcare.02452 http://rc.rcjournal.com/ http://rc.rcjournal.com/ http://rc.rcjournal.com/content/59/1/75 http://rc.rcjournal.com/content/59/1/75 AA00816862 0020-1324 Respiratory Care 59 1 75 80 https://kanazawa-u.repo.nii.ac.jp/record/58614/files/ME-PR-SOMEYA-F-59-75.pdf application/pdf 376.1 kB 2022-02-03