2026-03-07T12:59:13Z https://kanazawa-u.repo.nii.ac.jp/oai

oai:kanazawa-u.repo.nii.ac.jp:00013605 2024-06-20T07:18:24Z 1132:1133:1134

Cardiac Event Risk in Japanese Subjects Estimated Using Gated Myocardial Perfusion Imaging, in Conjunction With Diabetes Mellitus and Chronic Kidney Disease 00167545 Nakajima, Kenichi Matsuo, Shinro Okuyama, Chio Hatta, Tsuguru Tsukamoto, Kazumasa Nishimura, Shigeyuki Yamashina, Akira Kusuoka, Hideo Nishimura, Tsunehiko Copyright (c) 2011 THE JAPANESE CIRCULATION SOCIETY Background: Cardiac event risk is estimated using quantitative gated myocardial perfusion imaging (MPI) and clinical background in patients with ischemic heart disease. The aim of the present study was to calculate major cardiac event risk and tabulate it in the Heart Risk Table for clinical use of risk stratification. Methods and Results: Multivariate logistic regression was performed based on a multicenter prognostic database (Japanese Assessment of Cardiac Events and Survival Study by Quantitative Gated Single-photon emission computed tomography [J-ACCESS investigation]) using MPI (n=2,395). The risk of major cardiac events (cardiac death, non-fatal myocardial infarction and heart failure requiring hospitalization) was estimated using age, ejection fraction (EF), estimated glomerular filtration rate (eGFR) and presence of diabetes mellitus (DM). Age-matched standard eGFR was determined in 77 subjects. Major cardiac event risk was calculated using the equation: risk (%/3 years)=1/(1+Exp(-(-4.699-0.0151×eGFR+0.7998×DM+0.0582×age+0.697×SSS-0.0359×EF))×100, where SSS refers to summed stress scores. Risk was determined without eGFR (the initial version) and using the present formula with eGFR (revised version), with consistent results. DM and chronic kidney disease were major determinants of cardiac events. Conclusions: Cardiac event risk was estimated using MPI defect score and left ventricular EF in conjunction with eGFR and the presence of DM. The risk table might be used for risk evaluation in Japanese patients undergoing MPI. (Circ J 2012; 76: 168-175) Japanese Circulation Society = 日本循環器学会 2011-11-19 2017-10-03 eng journal article VoR http://hdl.handle.net/2297/29742 https://kanazawa-u.repo.nii.ac.jp/records/13605 10.1253/circj.CJ-11-0857 http://www.j-circ.or.jp/english/ https://japanlinkcenter.org/JST.JSTAGE/circj/CJ-11-0857 AA11591968 1346-9843 Circulation Journal 76 1 168 175 https://kanazawa-u.repo.nii.ac.jp/record/13605/files/ME-PR-NAKAJIMA-K-168.pdf application/pdf 3.7 MB 2017-10-03