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        <datestamp>2024-07-01T05:48:37Z</datestamp>
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          <dc:title>実験的緑内障濾過手術におけるハニカムフィルムの有用性</dc:title>
          <dc:title xml:lang="en">A honeycom-patterned film in experimental glaucoma filtration surgery</dc:title>
          <jpcoar:creator>
            <jpcoar:nameIdentifier nameIdentifierURI="https://kaken.nii.ac.jp/ja/search/?qm=10361990" nameIdentifierScheme="e-Rad_Researcher">10361990</jpcoar:nameIdentifier>
            <jpcoar:creatorName>奥田, 徹彦</jpcoar:creatorName>
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          <datacite:description descriptionType="Abstract">0.5マイクログラムパクリタキセル含有ハニカムフィルムは長期においても、眼圧下降効果を維持しつつ濾過胞瘢痕化抑制及び有血管濾過胞形成に有用であった。マイトマイシンCと比較した場合、眼圧下降効果は同等で有血管性濾過胞形成には著明な効果を示したが、長期的にはマイトマイシンCより濾過胞が瘢痕化する傾向にあった。また本フィルムは術後4種間まで薬剤を溶出しており、創傷治癒反応抑制に十分な速度で溶出した。</datacite:description>
          <datacite:description descriptionType="Abstract">Pacritaxel released from honeycomb-patterned film promoted bleb survival and IOP decrease. The lowest dose of pacritaxel (0.5 &amp;micro;g) was effective at preventing bleb avascularity without compromising filtration. Compared with mitomycin C eyes, bleb became flattened in pacritaxel-treated eyes. In addtion, the release profile of pacritaxel in our honeycomb-patterned film carrier may be appropriate to suppress the major proliferative stage of wound healing.</datacite:description>
          <datacite:description descriptionType="Other">出典：研究課題「実験的緑内障濾過手術におけるハニカムフィルムの有用性」課題番号25462706
（KAKEN：科学研究費助成事業データベース（国立情報学研究所））
（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25462706/25462706seika/）を加工して作成</datacite:description>
          <datacite:description descriptionType="Other">金沢大学附属病院眼科</datacite:description>
          <datacite:date dateType="Issued">2016-09-21</datacite:date>
          <dc:language>jpn</dc:language>
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          <jpcoar:identifier identifierType="DOI">https://doi.org/10.24517/00051585</jpcoar:identifier>
          <jpcoar:identifier identifierType="HDL">http://hdl.handle.net/2297/00051585</jpcoar:identifier>
          <jpcoar:identifier identifierType="URI">https://kanazawa-u.repo.nii.ac.jp/records/45246</jpcoar:identifier>
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            <jpcoar:relatedIdentifier identifierType="URI">https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25462706/</jpcoar:relatedIdentifier>
            <jpcoar:relatedTitle>https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25462706/</jpcoar:relatedTitle>
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            <jpcoar:relatedIdentifier identifierType="URI">https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25462706/25462706seika/</jpcoar:relatedIdentifier>
            <jpcoar:relatedTitle>https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25462706/25462706seika/</jpcoar:relatedTitle>
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          <jpcoar:sourceTitle>平成26(2014)年度 科学研究費補助金 基盤研究(C) 研究成果報告書</jpcoar:sourceTitle>
          <jpcoar:sourceTitle xml:lang="en">2014 Fiscal Year Final Research Report</jpcoar:sourceTitle>
          <jpcoar:volume>2013-04-01 - 2016-03-31</jpcoar:volume>
          <jpcoar:pageStart>4p.</jpcoar:pageStart>
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            <datacite:date dateType="Available">2018-07-09</datacite:date>
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