2026-03-08T14:24:05Z https://kanazawa-u.repo.nii.ac.jp/oai

oai:kanazawa-u.repo.nii.ac.jp:00014911 2024-06-20T06:50:17Z 1132:1133:1135

Lactams. XX. Decarboxylation of Unsaturated Acids incorporated into Six-Membered Lactam Systems Fujii, Tozo 26775 Ohba, Masashi 26369 60115219 60115219 Kogen, Hiroshi 26776 Ueda, Yuko 26777 The thermal decarboxylation of some unsaturated acids (1,5,6,8,and 9) incorporated into six-membered lactams was examined. Although 8 and 9 did not undergo decarboxylation when heated neat at 175-180℃ and 240-245℃, respectively, for 2 h, 1,5,and 6 were decarboxylated in 1,1,2,2-tetrachloroethane at 135℃. The relative ease of the reaction was in the order of 1≥6≫5. In the case of 1,the rate-decreasing effects observed on dilution and on the addition of trichloroacetic acid suggest the reaction to be a dimeric intermolecular process. journal article 日本薬学会 1981-11-25 VoR application/pdf Chemical & pharmaceutical bulletin 11 29 3392 3397 AA00602100 0009-2363 https://kanazawa-u.repo.nii.ac.jp/record/14911/files/PH-PR-OHBA-M-3392.pdf http://hdl.handle.net/2297/7623 https://kanazawa-u.repo.nii.ac.jp/records/14911 eng 10.1248/cpb.29.3392