2026-03-09T18:56:13Z https://kanazawa-u.repo.nii.ac.jp/oai

oai:kanazawa-u.repo.nii.ac.jp:00015091 2024-06-27T01:20:32Z 4281:4291:4312

小児と成人におけるボリコナゾールの血中濃度解析の比較 Comparison of Relationship between Dosage and Serum Concentration of Voriconazole in Adult and Pediatric Patients Ito, Satsuki Ishizaki, Junko Koshibata, Mikie Igarashi, Yasuro Nagata, Naoto Suga, Yukio Nishimura, Ryosei Maeba, Hideaki Koizumi, Shoichi Nakao, Shinji Yokogawa, Koichi Sai, Yoshimichi Miyamoto, Ken-ichi 伊藤, さつき 27158 石崎, 純子 640 60401890 60401890 小柴, 美紀恵 27159 五十嵐, 康郎 27160 長田, 直人 568 70456408 70456408 菅, 幸生 27049 00467101 00467101 西村, 良成 24453 50324116 50324116 前馬, 秀明 27161 小泉, 晶一 235 50019973 50019973 中尾, 眞二 71 70217660 70217660 70217660 横川, 弘一 22233 50283122 崔, 吉道 86 40262589 40262589 40262589 宮本, 謙一 22059 30100514 The purpose of this study was to investigate whether the trough plasma concentration of voriconazole (VRCZ) in the steady-state (Cmin) influences efficacy and safety in adult and pediatric patients. Treatment was successful in 75% of pediatric patients and 56% of adult patients,and there was no association between Cmin and efficacy.However,liver dysfunction occurred more frequently in the case that Cmin was over 4μg/mL in both adult and pediatric patients.Also,pediatric patients,especially those younger than 2 years,required a higher dose of VRCZ than adults to achieve a similar Cmin. We concluded that the use of VRCZ at a constant dose over a long period may lead to an increase in Cmin.Therefore,careful,continuous monitoring of the Cmin of VRCZ is necessary for pediatric patients,particularly recipients of hematopoietic stem cell transplantation. journal article 日本医療薬学会 = Japanese Society of Pharmaceutical Health Care and Sciences 2010-01-01 VoR application/pdf 医療薬学 4 36 213 219 AA11527197 1346-342X https://kanazawa-u.repo.nii.ac.jp/record/15091/files/PH-PR-ISHIZAKI-J-213.pdf https://doi.org/10.24517/00015078 http://hdl.handle.net/2297/36917 https://kanazawa-u.repo.nii.ac.jp/records/15091 jpn 10.5649/jjphcs.36.213 https://www.jstage.jst.go.jp/browse/jjphcs/36/4/_contents/-char/ja/ http://www.jsphcs.jp/ Copyright © 2010 日本医療薬学会 Japanese Society of Pharmaceutical Health Care and Sciences