2026-03-10T03:54:49Z https://kanazawa-u.repo.nii.ac.jp/oai

oai:kanazawa-u.repo.nii.ac.jp:00058614 2024-06-20T07:07:14Z 1132:1133:1134

Predictors of exercise-induced oxygen desaturation in systemic sclerosis patients with interstitial lung disease 染矢, 富士子 麦井, 直樹 Someya, Fujiko 84799 60187903 Mugii, Naoki 22608 Hasegawa, Minoru 104027 Yahata, Tetsutarou 22656 Nakagawa, Takao 22657 40217675 40217675 Background: The diffusion capacity of the lung for carbon monoxide (DLCO) is a good marker of disease severity in patients with idiopathic interstitial pneumonia, and is associated with oxygen saturation; however, little is known about DLCO in systemic sclerosis patients with interstitial lung disease. We studied potential predictors of exercise-induced oxygen desaturation in patients with systemic sclerosis. Methods: Data were collected prospectively from 80 of 110 consecutive systemic sclerosis patients with normal oxygen saturation (> 95%) at rest, who could perform the 6-min walk test without physical discomfort, including leg pain. Pulmonary function tests and echocardiography were collected from all subjects. Results: Thirty subjects showed a ≥ 4% decline in oxygen saturation during the 6-min walk test (desaturation group). The other subjects were assigned to the normoxic group. The percent-of-predicted values for FVC, FEV1, total lung capacity, DLCO, and DLCO/alveolar volume were lower, and FEV1/FVC was higher, in the desaturation group. Logistic regression analysis showed the percent-of-predicted DLCO as a highly accurate predictor of exercise-induced oxygen desaturation: the area under the receiver operating characteristic curve was 0.92 (cutoff point 56.3%, sensitivity 0.83, specificity 0.86). Five subjects over the cutoff point of the percent-of-predicted DLCO in the desaturation group could not be distinguished from the normoxic subjects with the lung-volume measurements or right-ventricular systolic pressure. Conclusions: The factor underlying exercise-induced oxygen desaturation appeared to be reduced percent-of-predicted DLCO, which was useful as a predictor in over 80% of the subjects. © 2014 Daedalus Enterprises. 金沢大学医薬保健研究域保健学系 journal article American Association for Inhalation Therapy 2014-01 VoR application/pdf Respiratory Care 1 59 75 80 AA00816862 0020-1324 https://kanazawa-u.repo.nii.ac.jp/record/58614/files/ME-PR-SOMEYA-F-59-75.pdf https://doi.org/10.24517/00064882 http://hdl.handle.net/2297/00064882 https://kanazawa-u.repo.nii.ac.jp/records/58614 eng 10.4187/respcare.02452 http://rc.rcjournal.com/ http://rc.rcjournal.com/ http://rc.rcjournal.com/content/59/1/75 http://rc.rcjournal.com/content/59/1/75 Copyright © 2014 Daedalus Enterprises, published by the American Association for Inhalation Therapy