@article{oai:kanazawa-u.repo.nii.ac.jp:00010465, author = {藤波, 修平 and 添田, 貴宏 and 猪股, 勝彦 and 宇梶, 裕 and Yoshida, Mari and Sassa, Naotaro and Kato, Tomomitsu and Fujinami, Shuhei and Soeta, Takahiro and Inomata, Katsuhiko and Ukaji, Yutaka}, issue = {7}, journal = {Chemistry - A European Journal}, month = {Feb}, note = {Desymmetrization of the divinyl carbinol 1,4-pentadien-3-ol was accomplished by the asymmetric 1,3-dipolar cycloaddition of azomethine imines based on a magnesium-mediated, multinucleating chiral reaction system utilizing diisopropyl (R,R)-tartrate as the chiral auxiliary. The corresponding optically active trans-pyrazolidines, each with three contiguous stereogenic centers, were obtained with excellent regio-, diastereo-, and enantioselectivity, with results as high as 99%ee. This reaction was shown to be applicable to both aryl- and alkyl-substituted azomethine imines. The use of a catalytic amount of diisopropyl (R,R)-tartrate was also effective when accompanied by the addition of MgBr2. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.}, pages = {2058--2064}, title = {Desymmetrization of 1,4-pentadien-3-ol by the asymmetric 1,3-dipolar cycloaddition of azomethine imines}, volume = {20}, year = {2014} }