@article{oai:kanazawa-u.repo.nii.ac.jp:00010629,
 author = {内橋, 貴之 and 柴田, 幹大 and 安藤, 敏夫 and Watanabe, Hiroki and Uchihashi, Takayuki and Kobashi, Toshihide and Shibata, Mikihiro and Nishiyama, Jun and Yasuda, Ryohei and Ando, Toshio},
 issue = {5},
 journal = {Review of Scientific Instruments},
 month = {May},
 note = {High-speed atomic force microscopy (HS-AFM) has recently been established. The dynamic processes and structural dynamics of protein molecules in action have been successfully visualized using HS-AFM. However, its maximum scan ranges in the X- and Y-directions have been limited to ∼1 μm and ∼4 μm, respectively, making it infeasible to observe the dynamics of much larger samples, including live cells. Here, we develop a wide-area scanner with a maximum XY scan range of ∼46 × 46 μm2 by magnifying the displacements of stack piezoelectric actuators using a leverage mechanism. Mechanical vibrations produced by fast displacement of the X-scanner are suppressed by a combination of feed-forward inverse compensation and the use of triangular scan signals with rounded vertices. As a result, the scan speed in the X-direction reaches 6.3 mm/s even for a scan size as large as ∼40 μm. The nonlinearity of the X- and Y-piezoelectric actuators' displacements that arises from their hysteresis is eliminated by polynomial-approximation-based open-loop control. The interference between the X- and Y-scanners is also eliminated by the same technique. The usefulness of this wide-area scanner is demonstrated by video imaging of dynamic processes in live bacterial and eukaryotic cells. © 2013 AIP Publishing LLC., 金沢大学ナノ生命科学研究所},
 title = {Wide-area scanner for high-speed atomic force microscopy},
 volume = {84},
 year = {2013}
}