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High-speed atomic force microscopy for observing protein molecules in dynamic action
http://hdl.handle.net/2297/47884
http://hdl.handle.net/2297/47884fb5dabb1-d0ae-482f-ac4e-0e209f6b6af7
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
SC-PR-ANDO-T-103281R.pdf (1.2 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-10-03 | |||||
| タイトル | ||||||
| タイトル | High-speed atomic force microscopy for observing protein molecules in dynamic action | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Ando, Toshio
× Ando, Toshio |
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| 書誌情報 |
Proceedings of SPIE - The International Society for Optical Engineering 巻 10328, p. 103281R, 発行日 2017-01-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0277-786X | |||||
| NCID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA10619755 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1117/12.2268795 | |||||
| 出版者 | ||||||
| 出版者 | SPIE | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Directly observing protein molecules in dynamic action at high spatiotemporal resolution has long been a holy grail for biological science. To materialize this long quested dream, I have been developing high-speed atomic force microscopy (HS-AFM) since 1993. Tremendous strides were recently accomplished in its high-speed and low-invasive performances. Consequently, various dynamic molecular actions, including bipedal walking of myosin V and rotary propagation of structural changes in F1-ATPase, were successfully captured on video. The visualized dynamic images not only provided irrefutable evidence for speculated actions of the protein molecules but also brought new discoveries inaccessible with other approaches, thus giving great mechanistic insights into how the molecules function. HS-AFM is now transforming "static" structural biology into dynamic structural bioscience. © 2017 SPIE. | |||||
| 権利 | ||||||
| 権利情報 | Copyright © 2017 SPIE | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 関連URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://proceedings.spiedigitallibrary.org/proceeding.aspx?articleid=2606340 | |||||
