@article{oai:kanazawa-u.repo.nii.ac.jp:00010852,
 author = {Ikuta, Naoko and Chikamoto, Keita and Asano, Yuya and Yasui, Yoshiaki and Yokokawa, Haruka and Terao, Keiji and Rimbach, Gerald and Matsugo, Seiichi},
 issue = {3},
 journal = {Journal of Medicinal Food},
 month = {Mar},
 note = {Alpha-lipoic acid (LA) is a powerful antioxidant. LA has two enantiomers, R(+)-LA (R-LA) and S(-)-LA (S-LA). Of these, R-LA is naturally occurring and an essential cofactor in energy metabolism. R-LA treatment has been reported to affect glucose metabolism in rat hepatoma cells. This study analyzed the time course of metabolite levels in LA-treated cultured H4IIEC3 rat hepatoma cells, including a specific evaluation of the effect of R-LA and the enantioselectivity of LA. Principal component analysis showed that this experiment was well designed to observe enantioselectivity. R-LA treatment was found to inhibit the glycolysis and Thr-Gly-Ser pathways, as well as lactic acid production, leading to the inhibition of gluconeogenesis in starved H4IIEC3 cells. This study may provide mechanistic insight into how R-LA induces apoptosis in hepatoma cells. © Copyright 2017, Mary Ann Liebert, Inc. and Korean Society of Food Science and Nutrition 2017., Embargo Period 12 months},
 pages = {211--222},
 title = {Time Course Effect of R-Alpha-Lipoic Acid on Cellular Metabolomics in Cultured Hepatoma Cells},
 volume = {20},
 year = {2017}
}