{"created":"2023-07-27T06:26:55.608156+00:00","id":10852,"links":{},"metadata":{"_buckets":{"deposit":"d2308a86-964b-4179-9acc-e37092181519"},"_deposit":{"created_by":3,"id":"10852","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"10852"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00010852","sets":["934:935:937"]},"author_link":["68845","68840","68842","311","68841","68844","68839","68843"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-03-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"222","bibliographicPageStart":"211","bibliographicVolumeNumber":"20","bibliographic_titles":[{"bibliographic_title":"Journal of Medicinal Food"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Alpha-lipoic acid (LA) is a powerful antioxidant. LA has two enantiomers, R(+)-LA (R-LA) and S(-)-LA (S-LA). Of these, R-LA is naturally occurring and an essential cofactor in energy metabolism. R-LA treatment has been reported to affect glucose metabolism in rat hepatoma cells. This study analyzed the time course of metabolite levels in LA-treated cultured H4IIEC3 rat hepatoma cells, including a specific evaluation of the effect of R-LA and the enantioselectivity of LA. Principal component analysis showed that this experiment was well designed to observe enantioselectivity. R-LA treatment was found to inhibit the glycolysis and Thr-Gly-Ser pathways, as well as lactic acid production, leading to the inhibition of gluconeogenesis in starved H4IIEC3 cells. This study may provide mechanistic insight into how R-LA induces apoptosis in hepatoma cells. © Copyright 2017, Mary Ann Liebert, Inc. and Korean Society of Food Science and Nutrition 2017.","subitem_description_type":"Abstract"}]},"item_4_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Embargo Period 12 months","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Mary Ann Liebert Inc."}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1089/jmf.2016.3837","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA11517488","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1096-620X","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ikuta, Naoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Chikamoto, Keita"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Asano, Yuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yasui, Yoshiaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yokokawa, Haruka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Terao, Keiji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Rimbach, Gerald"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsugo, Seiichi"}],"nameIdentifiers":[{},{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-02"}],"displaytype":"detail","filename":"SC-PR-MATSUGO-S-211.pdf","filesize":[{"value":"2.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"SC-PR-MATSUGO-S-211.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/10852/files/SC-PR-MATSUGO-S-211.pdf"},"version_id":"7898cacb-559a-44f8-9362-9d59a335e347"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Time Course Effect of R-Alpha-Lipoic Acid on Cellular Metabolomics in Cultured Hepatoma Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Time Course Effect of R-Alpha-Lipoic Acid on Cellular Metabolomics in Cultured Hepatoma Cells"}]},"item_type_id":"4","owner":"3","path":["937"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-12-05"},"publish_date":"2017-12-05","publish_status":"0","recid":"10852","relation_version_is_last":true,"title":["Time Course Effect of R-Alpha-Lipoic Acid on Cellular Metabolomics in Cultured Hepatoma Cells"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-27T17:47:23.454690+00:00"}