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Video imaging of walking myosin V by high-speed atomic force microscopy
https://doi.org/10.24517/00011073
https://doi.org/10.24517/000110731a7ac0e5-f0b0-4913-b717-bb6d6f5a5272
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
SC-PR-ANDO-T-2010.pdf (316.4 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2017-10-03 | |||||||||
| タイトル | ||||||||||
| タイトル | Video imaging of walking myosin V by high-speed atomic force microscopy | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| ID登録 | ||||||||||
| ID登録 | 10.24517/00011073 | |||||||||
| ID登録タイプ | JaLC | |||||||||
| 著者 |
Kodera, Noriyuki
× Kodera, Noriyuki× Yamamoto, Daisuke× Ishikawa, Ryoki× Ando, Toshio |
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| 著者別表示 |
古寺, 哲幸
× 古寺, 哲幸
× 安藤, 敏夫
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| 提供者所属 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 金沢大学ナノ生命科学研究所 / 金沢大学理工研究域数物科学系 | |||||||||
| 書誌情報 |
Nature 巻 468, 号 7320, p. 72-76, 発行日 2010-10-01 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 0028-0836 | |||||||||
| NCID | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA00752384 | |||||||||
| DOI | ||||||||||
| 関連タイプ | isVersionOf | |||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | 10.1038/nature09450 | |||||||||
| 出版者 | ||||||||||
| 出版者 | Nature Publishing Group | |||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | The dynamic behaviour of myosin V molecules translocating along actin filaments has been mainly studied by optical microscopy. The processive hand-over-hand movement coupled with hydrolysis of adenosine triphosphate was thereby demonstrated. However, the protein molecules themselves are invisible in the observations and have therefore been visualized by electron microscopy in the stationary states. The concomitant assessment of structure and dynamics has been unfeasible, a situation prevailing throughout biological research. Here we directly visualize myosin V molecules walking along actin tracks, using high-speed atomic force microscopy. The high-resolution movies not only provide corroborative 'visual evidence' for previously speculated or demonstrated molecular behaviours, including lever-arm swing, but also reveal more detailed behaviours of the molecules, leading to a comprehensive understanding of the motor mechanism. Our direct and dynamic high-resolution visualization is a powerful new approach to studying the structure and dynamics of biomolecules in action. | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | AM | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
