@article{oai:kanazawa-u.repo.nii.ac.jp:00012941,
 author = {Murase, Yuko and Yagi, Kunimasa and Sugihara, Masako and Chujo, Daisuke and Otsuji, Michiko and Muramoto, Hiroaki and Mabuchi, Hiroshi},
 issue = {9},
 journal = {Internal Medicine},
 month = {Sep},
 note = {Objective. The optimal approach to relatively recent onset type 2 diabetes patients is still unknown. We speculated that the use of short-acting insulin analogs might be of particular benefit in this context. Patients and Methods. To explore this possibility, we compared the effect on β- and α-cell function of transient intensive insulin therapy using lispro versus human regular insulin in a total of 21 type 2 diabetic patients who were randomly assigned to 14-days intensive insulin therapy consisting of bedtime NPH insulin plus three injections of mealtime lispro (n=11) or regular insulin (n=10). The dosages of both types of insulin were adjusted to attain preprandial glucose levels of <6.1 mmol/l within 1 week with similar rates of glucose decline. An oral glucose tolerance test (OGTT) was performed at day 0 (baseline), 7, and 14; plasma glucose, serum insulin, and plasma glucagon responses over 0-120 minutes were measured, and calculated as the area under the curve (AUC). Results. Lispro led to a significant reduction in glucose-AUC and also an increase in insulin-AUC versus regular insulin on day 7. Glucagon secretion following OGTT was well suppressed with lispro on day 14 compared to regular insulin. Conclusion. Two-week intensive insulin therapy with lispro appeared to be more effective than that with regular insulin in type 2 diabetes in attaining both more rapid β-cell rest and greater suppression of glucagon. These changes may provide significant long-term benefits., 金沢大学大学院医学系研究科},
 pages = {779--786},
 title = {Lispro is superior to regular insulin in transient intensive insulin therapy in type 2 diabetes},
 volume = {43},
 year = {2004}
}