@article{oai:kanazawa-u.repo.nii.ac.jp:00012948,
 author = {Takahashi, Naoki and Nakashima, Hiroshi},
 issue = {4},
 journal = {DNA Research},
 month = {Jan},
 note = {We conducted a genome-wide analysis of variations in guanine plus cytosine (G+C) content at the third codon position at silent substitution sites of orthologous human and mouse protein-coding nucleotide sequences. Alignments of 3776 human protein-coding DNA sequences with mouse orthologs having >50 synonymous codons were analyzed, and nucleotide substitutions were counted by comparing sequences in the alignments extracted from gap-free regions. The G+C content at silent sites in these pairs of genes showed a strong negative correlation (r = -0.93). Some gene pairs showed significant differences in G+C content at the third codon position at silent substitution sites. For example, human thymine-DNA glycosylase was A+T-rich at the silent substitution sites, while the orthologous mouse sequence was G+C-rich at the corresponding sites. In contrast, human matrix metalloproteinase 23B was G+C-rich at silent substitution sites, while the mouse ortholog was A+T-rich. We discuss possible implications of this significant negative correlation of G+C content at silent sites. © The Author 2006. Kazusa DNA Research Institute., 金沢大学大学院医学系研究科病態検査学},
 pages = {135--140},
 title = {Negative correlation of G+C content at silent substitution sites between orthologous human and mouse protein-coding sequences},
 volume = {13},
 year = {2006}
}