{"created":"2023-07-27T06:28:24.100126+00:00","id":12948,"links":{},"metadata":{"_buckets":{"deposit":"c647c4b0-f3ed-4ddb-b3a2-7772f4623c8f"},"_deposit":{"created_by":3,"id":"12948","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"12948"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00012948","sets":["1132:1133:1134"]},"author_link":["20087","680"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-01-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"140","bibliographicPageStart":"135","bibliographicVolumeNumber":"13","bibliographic_titles":[{"bibliographic_title":"DNA Research"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We conducted a genome-wide analysis of variations in guanine plus cytosine (G+C) content at the third codon position at silent substitution sites of orthologous human and mouse protein-coding nucleotide sequences. Alignments of 3776 human protein-coding DNA sequences with mouse orthologs having >50 synonymous codons were analyzed, and nucleotide substitutions were counted by comparing sequences in the alignments extracted from gap-free regions. The G+C content at silent sites in these pairs of genes showed a strong negative correlation (r = -0.93). Some gene pairs showed significant differences in G+C content at the third codon position at silent substitution sites. For example, human thymine-DNA glycosylase was A+T-rich at the silent substitution sites, while the orthologous mouse sequence was G+C-rich at the corresponding sites. In contrast, human matrix metalloproteinase 23B was G+C-rich at silent substitution sites, while the mouse ortholog was A+T-rich. We discuss possible implications of this significant negative correlation of G+C content at silent sites. © The Author 2006. Kazusa DNA Research Institute.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学大学院医学系研究科病態検査学","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Kazusa DNA Research Institute"}]},"item_4_publisher_19":{"attribute_name":"出版者（別名）","attribute_value_mlt":[{"subitem_publisher":"かずさDNA研究所"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1093/dnares/dsl007","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1340-2838","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takahashi, Naoki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakashima, Hiroshi"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-NAKASHIMA-H-135.pdf","filesize":[{"value":"358.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-NAKASHIMA-H-135.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/12948/files/ME-PR-NAKASHIMA-H-135.pdf"},"version_id":"f6525b5b-5e5e-4af3-beac-7ac13b901a0b"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Negative correlation of G+C content at silent substitution sites between orthologous human and mouse protein-coding sequences","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Negative correlation of G+C content at silent substitution sites between orthologous human and mouse protein-coding sequences"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"12948","relation_version_is_last":true,"title":["Negative correlation of G+C content at silent substitution sites between orthologous human and mouse protein-coding sequences"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T11:25:52.885004+00:00"}