@article{oai:kanazawa-u.repo.nii.ac.jp:00012970,
 author = {Okumura, Hirokazu and Yamaguchi, Masaki and Kotani, Takeharu and Sugimori, Naomi and Sugimori, Chiharu and Ozaki, Jun and Kondo, Yukio and Yamazaki, Hirohito and Chuhjo, Tatsuya and Takami, Akiyoshi and Ueda, Mikio and Ohtake, Shigeki and Nakao, Shinji},
 issue = {2},
 journal = {European Journal of Haematology},
 month = {Feb},
 note = {Human leukocyte antigen (HLA)-mismatched stem cell transplantation from non-inherited maternal antigen (NIMA)-complementary donors is known to produce stable engraftment without inducing severe graft-versus-host disease (GVHD). We treated two patients with acute myeloid leukemia (AML) and one patient with severe aplastic anemia (SAA) with HLA-mismatched stem cell transplantation (SCT) from NIMA-complementary donors (NIMA-mismatched SCT). The presence of donor and recipient-derived blood cells in the peripheral blood of recipient (donor microchimerism) and donor was documented respectively by amplifying NIMA-derived DNA in two of the three patients. Graft rejection occurred in the SAA patient who was conditioned with a fludarabine-based regimen. Grade III and grade IV acute GVHD developed in patients with AML on day 8 and day 11 respectively, and became a direct cause of death in one patient. The findings suggest that intensive conditioning and immunosuppression after stem cell transplantation are needed in NIMA-mismatched SCT even if donor and recipient microchimerisms is detectable in the donor and recipient before SCT. © 2007 The Authors., 金沢大学大学院医学系研究科機能再生学},
 pages = {157--160},
 title = {Graft rejection and hyperacute graft-versus-host disease in stem cell transplantation from non-inherited maternal antigen complementary HLA-mismatched siblings},
 volume = {78},
 year = {2007}
}