@article{oai:kanazawa-u.repo.nii.ac.jp:00012976, author = {Shimizu, Masami and Ino, Hidekazu and Okeie, Kazuyasu and Yamaguchi, Masato and Nagata, Mitsuru and Hayashi, Kenshi and Itoh, Hideki and Iwaki, Taku and Oe, Kotaro and Konno, Tetsuo and Taki, Junichi and Mabuchi, Hiroshi}, issue = {4}, journal = {Japanese Circulation Journal}, month = {Jan}, note = {Left ventricular function and blood pressure responses were evaluated in 56 patients with non-obstructive hypertrophic cardiomyopathy (HCM) and 12 control subjects by using a radionuclide ventricular function monitor during supine ergometer exercise. Patients with HCM were divided into 2 groups: (i) group A had no decrease in ejection fraction (EF) during exercise; and (ii) group B had a decrease in EF during exercise. During exercise, the change in end-diastolic volume did not differ between the 3 groups. In contrast, the change in end-systolic volume differed between the 3 groups (p<0.0001). The change in systolic blood pressure (SBP) also differed significantly between the 3 groups. The change in SBP in group B was smaller than that in the control group and group A, and changes in the EF and changes in the SBP between rest and peak exercise showed a significant correlation (p<0.005). These results suggest that exercise-induced systolic dysfunction in patients with non-obstructive HCM may contribute to abnormal blood pressure response in those patients., 金沢大学大学院医学系研究科}, pages = {325--329}, title = {Systolic dysfunction and blood pressure responses to supine exercise in patients with hypertrophic cardiomyopathy}, volume = {65}, year = {2001} }