@article{oai:kanazawa-u.repo.nii.ac.jp:00012992,
 author = {須釜, 聡 and 立野, 勝彦 and 灰田, 信英},
 issue = {5},
 journal = {理学療法学},
 month = {Sep},
 note = {関節拘縮発生にはコラーゲン中の架橋結合が関与し, この架橋結合はコラーゲンの可溶性に影響を及ぼす。我々は1および3週間ラットの足関節を固定しヒラメ筋コラーゲンの可溶性変化を報告した。今回,同様の関節固定期間が腱コラーゲンの可溶性に及ぼす影響を検索し, 架橋結合の変化を推察した。結果は, 1週および3週間の固定により中性塩可溶コラーゲンが有意に減少したが, 酸可溶および不溶性コラーゲン量に有意差はなかった。また不溶性コラーゲンのペプシン消化率についても変化は生じなかった。以上の結果から, 3週間の固定ではコラーゲンの可溶性に著明な変化は生じず, コラーゲン架橋結合にも顕著な影響を及ぼさないと推察される。 The purpose of this study was to investigate the change in solubility of immobilized Achilles tendon. Left hind limb of five rats were immobilized one week and other five rats were immobilized three weeks. Hydroxyproline was determined for the estimation of the collagen content in neutral salt soluble, acid soluble and insoluble collagen. In addition, insoluble collagen was digested with pepsin to determine solubility of insoluble collagen. Collagen content to represent as a percent of tendon weight did not change significantly during three weeks immobilization. The percentage of the salt soluble collagen to the total collagen was decreased significantly in one week and three weeks immobilization. The percentage of the acid soluble and insoluble collagen to the total collagen did not change significantly during three weeks immobilization. In the insoluble collagen, a rate of solubility with pepsin did not change significantly during three weeks immobilization. These results suggest that 1) Collagen concentration in Achilles tendon did not change during three weeks immobilization. 2) Solubility of Achilles tendon collagen, which is affected by intra- and intermolecular cross-links, does not remarkably change during three weeks immobilization., 金沢大学大学院医学系研究科機能障害学},
 pages = {196--201},
 title = {関節固定が腱組織コラーゲンの可溶性に及ぼす影響 : ラットアキレス腱におけるコラーゲンの生化学的分析},
 volume = {22},
 year = {1995}
}