{"created":"2023-07-27T06:28:27.215479+00:00","id":13020,"links":{},"metadata":{"_buckets":{"deposit":"70f00800-86d3-4131-b470-d7368c8051bb"},"_deposit":{"created_by":3,"id":"13020","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"13020"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00013020","sets":["1132:1133:1134"]},"author_link":["20387","20381","20218","20388","20382","20386","20385","20384","20383"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-09-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"229","bibliographicPageStart":"224","bibliographicVolumeNumber":"361","bibliographic_titles":[{"bibliographic_title":"Biochemical and Biophysical Research Communications"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The control of the stem cell compartment in epidermis is closely linked to the regulation of keratinocyte proliferation and differentiation. β1 integrins are expressed 2-fold higher by stem cells than transit-amplifying cells. Signaling from these β1 integrins is critical for the regulation of the epidermal stem cell compartment. To clarify the functional relevance of this differential expression of β1 integrins, we established HaCaT cells with high β1integrin expression by repeated flow cytometric sorting of this population from the parental cell line. In these obtained cells expressing β1 integrins by 5-fold, MAPK activation was markedly increased. Regarding the upstream of MAPK, Gab1 phosphorylation was also higher with high β1 integrin expression, while Shc phosphorylation was not altered. In addition, enhanced phosphatidylinositol 3-kinase activation was also observed. These observations suggest that Gab1 and phosphatidylinositol 3-kinase play pivotal roles in the β1 integrin-mediated regulation of the epidermal stem cell compartment. © 2007 Elsevier Inc. All rights reserved.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学大学院医学系研究科血管分子科学","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.bbrc.2007.07.017","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.elsevier.com/locate/issn/0006291X","subitem_relation_type_select":"URI"}}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0006-291X","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kuwano, Yoshihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujimoto, Manabu"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Watanabe, Rei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishiura, Nobuko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakashima, Hiroko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Komine, Mayumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hamazaki, Tatsuo S."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tamaki, Kunihiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okochi, Hitoshi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-FUJIMOTO-M-224.pdf","filesize":[{"value":"410.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-FUJIMOTO-M-224.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/13020/files/ME-PR-FUJIMOTO-M-224.pdf"},"version_id":"a34739f3-feb8-4d63-a6a9-8e3ffef6ccb4"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The involvement of Gab1 and PI 3-kinase in β1 integrin signaling in keratinocytes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The involvement of Gab1 and PI 3-kinase in β1 integrin signaling in keratinocytes"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"13020","relation_version_is_last":true,"title":["The involvement of Gab1 and PI 3-kinase in β1 integrin signaling in keratinocytes"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T01:11:33.272363+00:00"}